ArticlePhysiological reports2021
Volatile organic compounds (VOCs) in exhaled breath as a marker of hypoxia in multiple chemical sensitivity.
Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Exercise and Sports Metabolomics: Analytical Platforms, Metabolite Annotation, Pathway-Level Interpretation, and Biomarker-Panel Readiness.Metabolites · 2026Review
- Toward Linking Indoor Commercial Source Emissions to Outdoor Volatile Organic Compounds Using Mobile Measurements.ACS ES&T air · 2026Article
- Effect of E-Beam and X-Ray Irradiation on Radiation-Chemical Yield and Reaction Rate of Volatile Organic Compound Transformations.Molecules (Basel, Switzerland) · 2025Article
- HEX-1 reduces colitis-driven colorectal cancer via inactivating the prolyl isomerase PIN1 sensitization and remodeling the gut microbiota.Discover oncology · 2025Article
- Electronic Nose Analysis of Exhaled Breath Volatile Organic Compound Profiles during Normoxia, Hypoxia, and Hyperoxia.Molecules (Basel, Switzerland) · 2024Article
- A Concise Review of Exhaled Breath Testing for Respiratory Clinicians and Researchers.Respiratory care · 2024Review
- Exhaled breath condensate contains extracellular vesicles (EVs) that carry miRNA cargos of lung tissue origin that can be selectively purified and analyzed.Journal of extracellular vesicles · 2024Article
- Volabolomic Fingerprinting for Post-Mortem Interval Estimation: A Novel Physiological Approach.Biomolecules · 2024Article
- Advances in Respiratory Monitoring: A Comprehensive Review of Wearable and Remote Technologies.Biosensors · 2024Review
- The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: an observational study.Frontiers in medicine · 2024Article
- Molecular monitoring of lung allograft health: is it ready for routine clinical use?European respiratory review : an official journal of the European Respiratory Society · 2023Review
- GC/MS analysis of hypoxic volatile metabolic markers in the MDA-MB-231 breast cancer cell line.Frontiers in molecular biosciences · 2023Article
- Volatile organic compounds (VOCs) in exhaled breath as a marker of hypoxia in multiple chemical sensitivity.Physiological reports · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the history of diagnostics, breath analysis was one of the first method used until the breakthrough of biochemical testing technology. Today, breath analysis has made a comeback with the development of gas analyzers and e-noses, demonstrating its power in its applicability for diagnosing a wide range of diseases. The physical basis of multiple chemical sensitivity (MCS), an emerging environmental disease, is difficult to understand because it is based on the scenario of chronic hypoxia, with a complex of chemical compounds that trigger the syndrome and result in multiple symptoms. The aim of this study was to investigate MCS by analyzing exhaled volatile organic compounds (VOCs). The volatile, metabolic picture could be a putative gold standard for understanding and diagnosing the disease. The study was based on recording in resting condition using the noninvasive passive e-nose contactless breath test, the Olfactory Real-Time Volatile Organic Compounds (ORT-VOC) test in MCS, and control samples. The VOCs profile distinguished between disease and health. It also distinguished the gender-related volatile profile with significant robustness. The results trace a putative compensatory physiological pathway elicited by increased lactate, leading to acidosis, and hyperventilation, resulting in the production of specific VOCs. We conclude that breath testing is a valuable tool to investigate the hypoxia-related VOC profile, facilitating MCS diagnosis.
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