ArticleESC heart failure2021
Acute myocarditis after COVID-19 vaccination with mRNA-1273 in a patient with former SARS-CoV-2 infection.
Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 6 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Occurrence of Myocarditis in Patients Immunized with Different Types of COVID-19 Vaccines: A Systematic Review and Meta-Analysis.Virus research · 2026Pooled it
- Myocarditis and coronavirus disease 2019 vaccination: A systematic review and meta-summary of cases.Biomolecules & biomedicine · 2023Pooled it
- Cardiac MRI Findings in COVID-19 Vaccine-Related Myocarditis: A Pooled Analysis of 468 Patients.Journal of magnetic resonance imaging : JMRI · 2022Pooled it
- Myocarditis after COVID-19 mRNA vaccination: A systematic review of case reports and case series.Clinical cardiology · 2022Pooled it
- Global reports of myocarditis following COVID-19 vaccination: A systematic review and meta-analysis.Diabetes & metabolic syndrome · 2022Pooled it
- Myocarditis Following COVID-19 Vaccination: A Systematic Review of Case Reports.The Yale journal of biology and medicine · 2022Pooled it
- Mechanistic insights into COVID-19 mRNA vaccine-associated myocarditis: a bioinformatics analysis.American journal of translational research · 2025Article
- Myocarditis Associated with COVID-19 Vaccination.Vaccines · 2024Review
- COVID-19 vaccine-related myocarditis: Could antipyretic drugs be a trigger?Infectious medicine · 2023Article
- Myocardial Injury and Altered Gene Expression Associated With SARS-CoV-2 Infection or mRNA Vaccination.JACC. Basic to translational science · 2023Article
- Diagnostics of messenger ribonucleic acid (mRNA) severe acute respiratory syndrome-corona virus‑2 (SARS-CoV‑2) vaccination-associated myocarditis-A systematic review.Rechtsmedizin (Berlin, Germany) · 2023Review
- To Vaccinate or Not to Vaccinate-Reasons of Willingness and Reluctance of Students against SARS-CoV-2 Vaccination-An International Experience.International journal of environmental research and public health · 2022Article
- Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review.Journal of autoimmunity · 2022Review
- Acute Polyserositis with Cardiac Tamponade and Bilateral Refractory Pleural Effusion after ChAdOx1 nCoV-19 Vaccination.Vaccines · 2022Article
- Clinical Characteristics of Patients with Myocarditis following COVID-19 mRNA Vaccination: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Article
- Fulminant Myocarditis 24 Days after Coronavirus Disease Messenger Ribonucleic Acid Vaccination.Internal medicine (Tokyo, Japan) · 2022Article
- Myocarditis Following COVID-19 Vaccination: Cardiac Imaging Findings in 118 Studies.Tomography (Ann Arbor, Mich.) · 2022Review
- Prominent J Waves and Ventricular Fibrillation Caused by Myocarditis and Pericarditis After BNT162b2 mRNA COVID-19 Vaccination.The Canadian journal of cardiology · 2022Article
- Development of myocarditis and pericarditis after COVID-19 vaccination in adult population: A systematic review.Annals of medicine and surgery (2012) · 2022Review
- Myocarditis following COVID-19 vaccination: incidence, mechanisms, and clinical considerations.Expert review of cardiovascular therapy · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a case of a 20-year-old healthy man developing chest pain and classical symptoms of vaccine reactogenicity 12 h after receiving the first dose of mRNA-1273 (Moderna). Cardiac troponin T was increased, and subepicardial inflammation and focal contractile dysfunction were detected by cardiac magnetic resonance imaging and echocardiography. We confirmed the diagnosis of acute myocarditis by endomyocardial biopsy demonstrating significant infiltration of monocytes and T lymphocytes. Although we detected IgG against nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicating prior infection, the patient repeatedly tested negative for SARS-CoV-2 and had been asymptomatic for several months. Furthermore, viral genome analysis of endomyocardial biopsy samples was negative for SARS-CoV-2 and other potential cardiotropic viruses. These findings and the strong temporal relation between the vaccination and the symptom onset imply a potential side effect of mRNA-1273.
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Registered trials
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