Evidence map›Paper›PMID 34535983›Full record

ArticleCancer medicine2021

Association of dietary fat intake and hepatocellular carcinoma among US adults.

Iman Moussa, Rena S Day, Ruosha Li, Ahmed Kaseb, Prasun K Jalal, Carrie Daniel-MacDougall, Rikita I Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. CD36: The Bridge between Lipids and Tumors.Molecules (Basel, Switzerland) · 2024
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Iman MoussaDepartment of Epidemiology, Human Genetics, and Environmental Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0002-6171-8628
Rena S DayDivision of Epidemiology, Human Genetics, & Environmental Sciences, Southwest Center for Occupational and Environmental Health, Michael & Susan Dell Center for Healthy Living, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Ruosha LiDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Ahmed KasebDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.ORCID 0000-0002-9491-0587
Prasun K JalalDivision of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Carrie Daniel-MacDougallDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Rikita I HatiaDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Ahmed AbdelhakeemDepartment of Internal Medicine, Baptist Hospitals of Southeast Texas, Beaumont, Texas, USA.ORCID 0000-0001-7186-1332
Asif RashidDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Yun Shin ChunDivision of Surgery, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Donghui LiDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Manal M HassanDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
The University of Texas MD Anderson Cancer Center SPORE in Hepatocellular CarcinomaP50CA217674 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BERETTA, LAURA, KASEB, AHMED · 2019 to 2023
$11.3M
Genome-Wide Association Study (GWAS) in Hepatocellular Carcinoma (HCC)R01CA186566 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., HASSAN, MANAL METWALLY · 2015 to 2019
$3.6M
Molecular Epidemiology of Pancreatic CancerR01CA098380 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, DONGHUI · 2004 to 2008
$2.6M
Molecular Epidemiology of Chronic Liver DiseasesK07CA106458 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HASSAN, MANAL METWALLY · 2005 to 2009
$681k
NCI NIH HHS K07 CA106458NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA217674NCI NIH HHS R01 CA098380NCI NIH HHS R01 CA186566
6 · The paper itself

Abstract

BACKGROUND AND

aimsThe role of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) remains unclear. We investigated the associations of total fat and fatty acids with risk of HCC among US adults in a hospital-based case-control study.

methodsWe analyzed data from 641 cases and 1034 controls recruited at MD Anderson Cancer Center during 2001-2018. Cases were new patients with a pathologically or radiologically confirmed diagnosis of HCC; controls were cancer-free spouses of patients with cancers other than gastrointestinal, lung, liver, or head and neck. Cases and controls were frequency-matched by age and sex. Dietary intake was assessed using a validated food frequency questionnaire. Odds ratios (ORs) and corresponding confidence intervals (CIs) were computed using unconditional logistic regression with adjustment for major HCC risk factors, including hepatitis B virus and hepatitis C virus infection.

resultsMonounsaturated fatty acid (MUFA) intake was inversely associated with HCC risk (highest vs. lowest tertile: OR, 0.49; 95% CI, 0.33-0.72). Total polyunsaturated fatty acid (PUFA) intake was directly associated with HCC risk (highest vs. lowest tertile: OR, 1.82; 95% CI, 1.23-2.70). Omega-6 PUFA was directly associated with HCC risk (highest vs. lowest tertile: OR 2.29; 95% CI, 1.52-3.44). Long-chain omega-3 PUFA (eicosapentaenoic acid and docosahexaenoic acid) intake was also inversely associated with HCC risk (highest vs. lowest tertile: OR, 0.50; 95% CI, 0.33-0.70). No association was observed for saturated fat and HCC risk.

conclusionOur findings support a direct association of omega-6 PUFA intake with HCC and an inverse association of MUFA and long-chain omega-3 PUFA intake with HCC.

Indexed as

Carcinoma, HepatocellularCase-Control StudiesDietary FatsFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHepatitis BHepatitis CHumansLiver NeoplasmsMaleMiddle AgedRisk FactorsUnited StatesDietary FatsFatty Acids, Omega-3Fatty Acids, Omega-6case-controlliver cancermonounsaturated fatty acidsomega-3 fatty acidsomega-6 fatty acidspolyunsaturated fatty acids

Identifiers

PMID34535983
PMCPMC8525131

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.