ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022
Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
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17 citing papers in PubMed.
- Clinical phenotypes among patients that underwent cardiac resynchronization therapy using unsupervised learning integrating gated SPECT.Nuclear medicine communications · 2025Article
- Radiomics Nomogram Derived from Gated Myocardial Perfusion SPECT for Identifying Ischemic Cardiomyopathy.Journal of imaging informatics in medicine · 2024Article
- A predictive model of super response to cardiac resynchronization therapy in short-term period.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Heart failure in China: epidemiology and current management.Journal of geriatric cardiology : JGC · 2024Article
- 2022 Artificial intelligence primer for the nuclear cardiologist.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Deep learning-based diagnosis of disease activity in patients with Graves' orbitopathy using orbital SPECT/CT.European journal of nuclear medicine and molecular imaging · 2023Article
- Deep-learning-based methods of attenuation correction for SPECT and PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Deep-learning-based estimation of attenuation map improves attenuation correction performance over direct attenuation estimation for myocardial perfusion SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Left ventricular mechanical dyssnchrony: A potential new marker for 3-vessel CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Applying deep learning attenuation correction in the presence of motion.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic impact of cardiac resynchronization therapy guided by phase analysis: a CZT study.European heart journal. Imaging methods and practice · 2023Article
- Texture analysis of SPECT myocardial perfusion provides prognostic value for dilated cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: single photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- The Value of Left Ventricular Mechanical Dyssynchrony and Scar Burden in the Combined Assessment of Factors Associated with Cardiac Resynchronization Therapy Response in Patients with CRT-D.Journal of clinical medicine · 2023Article
- The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Identifying CRT responders: Moving from electrical to mechanical dyssynchrony.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- 'Do No Harm': optimizing protocol for FDG PET cardiac viability assessment.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
Corrections and comments
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- Erratum issued
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10 authors.
Funding
Abstract
backgroundCardiac resynchronization therapy (CRT) patients with different pathophysiology may influence mechanical dyssynchrony and get different ventricular resynchronization and clinical outcomes.
methodsNinety-two dilated cardiomyopathy (DCM) and fifty ischemic cardiomyopathy (ICM) patients with gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) were included in this retrospective study. Patients were classified based on the concordance between the left ventricular (LV) lead and the latest contraction or relaxation position. If the LV lead was located on or adjacent to both the latest contraction and relaxation position, the patient was categorized into the both match group; if the LV lead was located on or adjacent to the latest contraction or relaxation position, the patient was classified into the one match group; if the LV lead was located on or adjacent to neither the latest contraction nor relaxation position, the patient was categorized to the neither group. CRT response was defined as [Formula: see text] improvement of LV ejection fraction at the 6-month follow-up. Variables with P < .05 in the univariate analysis were included in the stepwise multivariate model.
resultsDuring the follow-up period, 58.7% (54 of 92) for DCM patients and 54% (27 of 50) for ICM patients were CRT responders. The univariate analysis and stepwise multivariate analysis showed that QRS duration, systolic phase bandwidth (PBW), diastolic PBW, diastolic phase histogram standard deviation (PSD), and left ventricular mechanical dyssynchrony (LVMD) concordance were independent predictors of CRT response in DCM patients; diabetes mellitus and left ventricular end-systolic volume were significantly associated with CRT response in ICM patients. The intra-group comparison revealed that the CRT response rate was significantly different in the both match group of DCM (N = 18, 94%) and ICM (N = 24, 62%) patients (P = .016). However, there was no significant difference between DCM and ICM in the one match and neither group. For the inter-group comparison, Kruskal-Wallis H-test revealed that CRT response was significantly different in all the groups of DCM patients (P < .001), but not in ICM patients (P = .383).
conclusionsCompared with ICM patients, systolic PBW, diastolic PBW and PSD have better predictive and prognostic values for the CRT response in DCM patients. Placing the LV lead in or adjacent to the latest contraction and relaxation position can improve the clinical outcomes of DCM patients, but it does not apply to ICM patients.
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