Evidence map›Paper›PMID 34535853›Full record

ArticleThe international journal of cardiovascular imaging2022

Prospective analysis of myocardial strain through the evolution of Chagas disease in the hamster animal model.

Fernando Fonseca França Ribeiro, Henrique Turin Moreira, Antônio Carlos Leite de Barros-Filho, Denise M Tanaka, Camila G Fabricio, Luciano F L Oliveira, Cibele M Prado, Marcus V Simões, André Schmidt, Benedito C Maciel and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Fernando Fonseca França RibeiroCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Henrique Turin MoreiraCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Antônio Carlos Leite de Barros-FilhoCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Denise M TanakaCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Camila G FabricioCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Luciano F L OliveiraPhysical Therapy Department, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Cibele M PradoAnimal Science and Food Engineering, University of São Paulo, USP, Pirassununga, São Paulo, 13635-900, Brazil.
Marcus V SimõesCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
André SchmidtCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Benedito C MacielCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
José A Marin-NetoCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil.
Minna Moreira Dias RomanoCardiology Division, Internal Medicine Department, Cardiology Center of the Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, Bandeirantes Avenue, 3900, Ribeirão Preto, São Paulo, 14049-900, Brazil. minna@fmrp.usp.br.ORCID http://orcid.org/0000-0002-8742-3764
Universidade de São Paulo · BRUniversidade de Ribeirão Preto · BRUniversidade Federal de Minas Gerais · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/25403-9
6 · The paper itself

Abstract

Speckle tracking echocardiography (STE) enables early diagnosis of myocardial damage by evaluating myocardial strain. We aimed to study sequential changes in structural and ventricular functional parameters during Chagas disease (CD) natural history in an animal model. 37 Syrian hamsters were inoculated intraperitoneally with Trypanosoma cruzi (Chagas) and 20 with saline (Control). Echocardiography was performed before the infection (baseline), at 1 month (acute phase), 4, 6, and 8 months (chronic phase) using Vevo 2100 (Fujifilm Inc.) ultrasound system. Left ventricular end-diastolic diameter, Left ventricular end-systolic diameter (LVESD), Left ventricular ejection fraction (LVEF), Global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were evaluated. Tricuspid annular plane systolic excursion (TAPSE) was used to assess right ventricular function. At 8 months, animals were euthanized and LV myocardial samples were analyzed for quantitation of inflammation and fibrosis. LVEF decreased over time in Chagas group and a difference from Control was detected at 6 months (p-value of groups#time interaction = 0.005). There was a pronounced decrease in GLS, GCS and TAPSE in Chagas group (p-value of groups#time interaction = 0.003 for GLS, < 0.001 for GCS and < 0.009 for TAPSE vs Control) since the first month. LVESD, LVEF and GLS were significantly correlated to the number of inflammatory cells (r = 0.41, p = 0.046; r = - 0.42, p = 0.042; r = 0.41, p = 0.047) but not to fibrosis. In the Syrian hamster model of CD STE parameters (GLS and GCS) showed an early decrease. Changes in LVEF, LVESD, and GLS were correlated to myocardial inflammation but not to fibrosis.

Indexed as

Chagas DiseaseVentricular Dysfunction, LeftAnimalsCricetinaeModels, AnimalPredictive Value of TestsStroke VolumeVentricular Function, LeftAnimal experimental modelChagas cardiomyopathyEchocardiographyHamstersSpeckle-trackingStrain

Identifiers

PMID34535853
PMCPMC8818632
OpenAlexW3127445893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.