Evidence map›Paper›PMID 34535847›Full record

ArticleJournal of assisted reproduction and genetics2021

Should there be an "AI" in TEAM? Embryologists selection of high implantation potential embryos improves with the aid of an artificial intelligence algorithm.

V W Fitz, M K Kanakasabapathy, P Thirumalaraju, H Kandula, L B Ramirez, L Boehnlein, J E Swain, C L Curchoe, K James, I Dimitriadis and 3 more

Abstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  11. A review of artificial intelligence applications in in vitro fertilization.Journal of assisted reproduction and genetics · 2025
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  19. New frontiers in embryo selection.Journal of assisted reproduction and genetics · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

V W FitzDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
M K KanakasabapathyDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
P ThirumalarajuDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
H KandulaDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
L B RamirezNorthwell Health Fertility, Manhasset, NY, USA.
L BoehnleinDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USA.
J E SwainCCRM Fertility Network, Lone Tree, CO, USA.
C L CurchoeCCRM Fertility Orange County, Newport Beach, CA, USA.
K JamesThe Deborah Kelly Center for Outcomes Research, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA.
I DimitriadisDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
I SouterDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
C L BormannDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. cbormann@partners.org.
H ShafieeDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. hshafiee@bwh.harvard.edu.

Funding

Microchip for HBV testing using HIV-infected blood samplesR01AI138800 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2019 to 2023
$3.1M
Sensitive and quantitative point-of-care viral load testing on paperR01AI118502 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2016 to 2020
$2.2M
NIAID NIH HHS R01 AI118502NIAID NIH HHS R01 AI138800NIH HHS R01AI118502NIH HHS R01AI138800
6 · The paper itself

Abstract

purposeA deep learning artificial intelligence (AI) algorithm has been demonstrated to outperform embryologists in identifying euploid embryos destined to implant with an accuracy of 75.3% (1). Our aim was to evaluate the performance of highly trained embryologists in selecting top quality day 5 euploid blastocysts with and without the aid of a deep learning algorithm. MATERIALS AND

methodsA non-overlapping series of 200 sets of day 5 euploid embryo images with known implantation outcomes was distributed to 17 highly trained embryologists. One embryo in each set was known to have implanted and one failed implantation. They were asked to select which embryo to transfer from each set. The same 200 sets of embryos, with indication of which embryo in each set had been identified by the algorithm as more likely to implant was then distributed. Chi-squared, t-test, and receiver operating curves were performed to compare the embryologist performeance with and without AI.

resultsFourteen embryologists completed both assessments. Embryologists provided with AI results selected successfully implanted embryos in 73.6% of cases compared to 65.5% for those selected using visual assessments alone (p < 0.001). All embryologists improved in their ability to select embryos with the aid of the AI algorithm with a mean percent improvement of 11.1% (range 1.4% to 15.5%). There were no differences in degree of improvement by embryologist level of experience (junior, intermediate, senior).

conclusionsThe incorporation of an AI framework for blastocyst selection enhanced the performance of trained embryologists in identifying PGT-A euploid embryos destined to implant.

Indexed as

AlgorithmsArtificial IntelligenceDecision Support TechniquesEmbryo ImplantationAdultBlastocystFemaleFertilization in VitroHumansImage Processing, Computer-AssistedPregnancyPregnancy RateRetrospective StudiesArtificial intelligenceAssisted reproductive technologyEmbryo selectionImplantation

Identifiers

PMID34535847
PMCPMC8581077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.