ArticleEuropean archives of psychiatry and clinical neuroscience2022
The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study.
Article in European archives of psychiatry and clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Disentangling white matter correlates of symptom severity and general impairment in early psychosis.Molecular psychiatry · 2026Article
- Increasing participation of people with thought disorder in clinical research.European psychiatry : the journal of the Association of European Psychiatrists · 2026Review
- Transdiagnostic types of formal thought disorder and their association with gray matter brain structure: a model-based cluster analytic approach.Molecular psychiatry · 2025Article
- Detection of formal thought disorders in child and adolescent psychosis using machine learning and neuropsychometric data.Frontiers in psychiatry · 2025Article
- Speech analytics across the schizophrenia spectrum disorders: multimodal natural language processing and machine learning modelling in a Chinese-speaking population.Frontiers in psychiatry · 2025Article
- Narrative Forewarnings: A Qualitative Analysis of the Themes Preceding Disorganized Speech in Schizophrenia.Behavioral sciences (Basel, Switzerland) · 2024Article
- Semantic Speech Networks Linked to Formal Thought Disorder in Early Psychosis.Schizophrenia bulletin · 2023Article
- Neural Correlates of Formal Thought Disorder Dimensions in Psychosis.Schizophrenia bulletin · 2023Article
- Whole Person Modeling: a transdisciplinary approach to mental health research.Discover mental health · 2023Review
- Linguistic findings in persons with schizophrenia-a review of the current literature.Frontiers in psychology · 2023Review
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Authors and funding
28 authors at 15 institutions in 7 countries.
Funding
Abstract
backgroundFormal thought disorder (FTD) has been associated with more severe illness courses and functional deficits in patients with psychotic disorders. However, it remains unclear whether the presence of FTD characterises a specific subgroup of patients showing more prominent illness severity, neurocognitive and functional impairments. This study aimed to identify stable and generalizable FTD-subgroups of patients with recent-onset psychosis (ROP) by applying a comprehensive data-driven clustering approach and to test the validity of these subgroups by assessing associations between this FTD-related stratification, social and occupational functioning, and neurocognition.
methods279 patients with ROP were recruited as part of the multi-site European PRONIA study (Personalised Prognostic Tools for Early Psychosis Management; www.pronia.eu). Five FTD-related symptoms (conceptual disorganization, poverty of content of speech, difficulty in abstract thinking, increased latency of response and poverty of speech) were assessed with Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS).
resultsThe results with two patient subgroups showing different levels of FTD were the most stable and generalizable clustering solution (predicted clustering strength value = 0.86). FTD-High subgroup had lower scores in social (p
conclusionsClustering techniques allowed us to identify patients with more pronounced FTD showing more severe deficits in functioning and neurocognition, thus suggesting that FTD may be a relevant marker of illness severity in the early psychosis pathway.
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