Evidence map›Paper›PMID 34535742›Full record

ArticleNPJ precision oncology2021

Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa.

Samuel Terkper Ahuno, Anna-Lisa Doebley, Thomas U Ahearn, Joel Yarney, Nicholas Titiloye, Nancy Hamel, Ernest Adjei, Joe-Nat Clegg-Lamptey, Lawrence Edusei, Baffour Awuah and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Contribution of Prediagnostic Host Factors to Shaping the Stromal Microenvironment of Breast Cancer among Sub-Saharan African Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Samuel Terkper AhunoDepartment of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Anna-Lisa DoebleyMolecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3371-3352
Thomas U AhearnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Joel YarneyKorle Bu Teaching Hospital, Accra, Ghana.
Nicholas TitiloyeKomfo Anokye Teaching Hospital, Kumasi, Ghana.
Nancy HamelResearch Institute of the McGill University Health Centre, Montréal, QC, Canada.
Ernest AdjeiKomfo Anokye Teaching Hospital, Kumasi, Ghana.
Joe-Nat Clegg-LampteyKorle Bu Teaching Hospital, Accra, Ghana.
Lawrence EduseiKorle Bu Teaching Hospital, Accra, Ghana.
Baffour AwuahKomfo Anokye Teaching Hospital, Kumasi, Ghana.
Xiaoyu SongDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Verna VanderpuyeKorle Bu Teaching Hospital, Accra, Ghana.
Mustapha AbubakarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3728-6535
Maire DugganDepartment of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0001-6625-7683
Daniel G StoverStefanie Spielman Comprehensive Breast Cancer, The Ohio State University, Columbus, OH, USA.
Kofi NyarkoUniversity of Ghana, Accra, Ghana.
John M S BartlettOntario Institute for Cancer Research, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-0347-3888
Francis AitpillahKomfo Anokye Teaching Hospital, Kumasi, Ghana.ORCID http://orcid.org/0000-0001-9495-6887
Daniel AnsongDepartment of Child Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Kevin L GardnerDepartment of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, USA.
Felix Andy BoatengKomfo Anokye Teaching Hospital, Kumasi, Ghana.
Anne M BowcockDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.
Carlos CaldasCancer Research UK Cambridge Centre, Cambridge, UK.ORCID http://orcid.org/0000-0003-3547-1489
William D FoulkesResearch Institute of the McGill University Health Centre, Montréal, QC, Canada.ORCID http://orcid.org/0000-0001-7427-4651
Seth WiafeSchool of Public Health, Loma Linda University, Loma Linda, CA, USA.ORCID http://orcid.org/0000-0001-6085-9405
Beatrice Wiafe-AddaiPeace and Love Hospital, Kumasi, Ghana.
Montserrat Garcia-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Alexander KwartengDepartment of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Gavin HaDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. gha@fredhutch.org.ORCID http://orcid.org/0000-0001-7578-7272
Jonine D FigueroaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Jonine.figueroa@ed.ac.uk.ORCID http://orcid.org/0000-0002-5100-623X
Paz PolakDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, USA. paz.polak@mssm.edu.ORCID http://orcid.org/0000-0002-2153-4488
Ghana Breast Health Study Team

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
THE GENETICS OF OCULAR MELANOMAR01CA161870 · NCI · WASHINGTON UNIVERSITY · PI BOWCOCK, ANNE MARY · 2011 to 2024
$5.5M
The linkage between Race, Kaiso and the tumor microenvironment in breast cancer health disparitiesR01CA253368 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GARDNER, KEVIN L. · 2020 to 2024
$3.3M
Identifying driver non-coding alterations in metastatic prostate cancer from tumor and cell-free DNAK22CA237746 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HA, GAVIN · 2020 to 2022
$568k
Cancer Research UK 16942Cancer Research UK 29567Medical Research Council MR/S015027/1NCI NIH HHS K22 CA237746NCI NIH HHS P30 CA013696NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA196521NCI NIH HHS R01 CA161870NCI NIH HHS R01 CA253368
6 · The paper itself

Abstract

Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Breast cancer driver copy number alterations were observed in the majority of patients.

Identifiers

PMID34535742
PMCPMC8448727

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.