ArticleScientific reports2021
Cognitive control affects motor learning through local variations in GABA within the primary motor cortex.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Transcranial direct current stimulation enhances motor learning in Parkinson's disease: a randomized controlled trial.Journal of neurology · 2023Trial
- The contributions of biological maturity and experience to fine motor development in adolescence.Scientific reports · 2026Article
- Hand Grip Strength Predicts Cognitive Decline in Subjective Cognitive Decline: 2-Year Follow-up Results.Journal of Korean medical science · 2026Article
- Concurrent observation and physical practice facilitates early closed motor skill learning: evidence from EEG source functional connectivity and behavioral performance.Frontiers in psychology · 2026Article
- The role of inhibitory and excitatory neurometabolites in age-related differences in action selection.npj aging · 2025Article
- The Reciprocal Relationship Between Short- and Long-Term Motor Learning and Neurometabolites.Human brain mapping · 2025Article
- Level of M1 GABAB predicts micro offline consolidation of motor learning during wakefulness.NPJ science of learning · 2025Article
- MRS-assessed brain GABA modulation in response to task performance and learning.Behavioral and brain functions : BBF · 2024Review
- Electroencephalogram Alpha Oscillations in Stroke Recovery: Insights into Neural Mechanisms from Combined Transcranial Direct Current Stimulation and Mirror Therapy in Relation to Activities of Daily Life.Bioengineering (Basel, Switzerland) · 2024Article
- Neural correlates of transfer of learning in motor coordination tasks: role of inhibitory and excitatory neurometabolites.Scientific reports · 2024Article
- Early excitatory-inhibitory cortical modifications following skill learning are associated with motor memory consolidation and plasticity overnight.Nature communications · 2024Article
- Plasticity-stability dynamics during post-training processing of learning.Trends in cognitive sciences · 2024Review
- Examination of acute spin exercise on GABA levels in aging and stroke: The EASE study protocol.PloS one · 2024Article
- Increased cortical inhibition following brief motor memory reactivation supports reconsolidation and overnight offline learning gains.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Are sleep disturbances a cause or consequence of autism spectrum disorder?Psychiatry and clinical neurosciences · 2023Article
- Article
- Decision heuristics in contexts integrating action selection and execution.Scientific reports · 2023Article
- Vector-based analysis of cortical activity associated with dumbbell exercise using functional near-infrared spectroscopy.Frontiers in sports and active living · 2022Article
- Theta-gamma coupling as a cortical biomarker of brain-computer interface-mediated motor recovery in chronic stroke.Brain communications · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary motor cortex (M1) is crucial for motor learning; however, its interaction with other brain areas during motor learning remains unclear. We hypothesized that the fronto-parietal execution network (FPN) provides learning-related information critical for the flexible cognitive control that is required for practice. We assessed network-level changes during sequential finger tapping learning under speed pressure by combining magnetic resonance spectroscopy and task and resting-state functional magnetic resonance imaging. There was a motor learning-related increase in preparatory activity in the fronto-parietal regions, including the right M1, overlapping the FPN and sensorimotor network (SMN). Learning-related increases in M1-seeded functional connectivity with the FPN, but not the SMN, were associated with decreased GABA/glutamate ratio in the M1, which were more prominent in the parietal than the frontal region. A decrease in the GABA/glutamate ratio in the right M1 was positively correlated with improvements in task performance (p = 0.042). Our findings indicate that motor learning driven by cognitive control is associated with local variations in the GABA/glutamate ratio in the M1 that reflects remote connectivity with the FPN, representing network-level motor sequence learning formations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.