Evidence map›Paper›PMID 34535656›Full record

ArticleNature communications2021

Spatially and optically tailored 3D printing for highly miniaturized and integrated microfluidics.

Jose L Sanchez Noriega, Nicholas A Chartrand, Jonard Corpuz Valdoz, Collin G Cribbs, Dallin A Jacobs, Daniel Poulson, Matthew S Viglione, Adam T Woolley, Pam M Van Ry, Kenneth A Christensen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 144 citations in OpenAlex.

  1. Article
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  4. In Situ Characterisation of Hydrogels via Dynamic Interface Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jose L Sanchez NoriegaElectrical and Computer Engineering Department, Brigham Young University, Provo, UT, 84602, USA.
Nicholas A ChartrandChemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602, USA.ORCID 0000-0002-2388-7770
Jonard Corpuz ValdozChemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602, USA.ORCID 0000-0002-7106-1009
Collin G CribbsChemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602, USA.
Dallin A JacobsChemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602, USA.
Daniel PoulsonChemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602, USA.ORCID 0000-0002-1471-1378
Matthew S ViglioneElectrical and Computer Engineering Department, Brigham Young University, Provo, UT, 84602, USA.
Adam T WoolleyChemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602, USA.
Pam M Van RyChemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602, USA.
Kenneth A ChristensenChemistry and Biochemistry Department, Brigham Young University, Provo, UT, 84602, USA.ORCID 0000-0002-3736-5500
Gregory P NordinElectrical and Computer Engineering Department, Brigham Young University, Provo, UT, 84602, USA. nordin@byu.edu.ORCID 0000-0001-7241-5764
Brigham Young University · US

Funding

High Density 3D Printed Microfluidics With Open Source Resins for Biomedical ApplicationsR15GM123405 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI NORDIN, GREGORY P. · 2017 to 2023
$1.3M
3D-Printed Integrated Microfluidic Devices for Preterm Birth Biomarker AnalysisR01EB027096 · NIBIB · BRIGHAM YOUNG UNIVERSITY · PI WOOLLEY, ADAM THOMAS · 2018 to 2021
$1.1M
NIBIB NIH HHS R01 EB027096NIGMS NIH HHS R15 GM123405
6 · The paper itself

Abstract

Traditional 3D printing based on Digital Light Processing Stereolithography (DLP-SL) is unnecessarily limiting as applied to microfluidic device fabrication, especially for high-resolution features. This limitation is due primarily to inherent tradeoffs between layer thickness, exposure time, material strength, and optical penetration that can be impossible to satisfy for microfluidic features. We introduce a generalized 3D printing process that significantly expands the accessible spatially distributed optical dose parameter space to enable the fabrication of much higher resolution 3D components without increasing the resolution of the 3D printer. Here we demonstrate component miniaturization in conjunction with a high degree of integration, including 15 μm × 15 μm valves and a 2.2 mm × 1.1 mm 10-stage 2-fold serial diluter. These results illustrate our approach's promise to enable highly functional and compact microfluidic devices for a wide variety of biomolecular applications.

Indexed as

MicrofluidicsMiniaturizationOptics and PhotonicsPrinting, Three-DimensionalMembranesPressureX-Ray Microtomography

Identifiers

PMID34535656
PMCPMC8448845
OpenAlexW3201209914

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.