ArticleNature communications2021
Incipient diploidization of the medicinal plant Perilla within 10,000 years.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Selection and Validation of Reference Genes for RT-qPCR Analysis of Lipid Biosynthesis-Related Genes inPlants (Basel, Switzerland) · 2026Article
- Progeny-based genomic selection reveals untapped genetic potential in an underutilized medicinal plant,Molecular breeding : new strategies in plant improvement · 2026Article
- Construction of high-density genetic map and QTL mapping of flowering traits in Perilla frutescens.BMC plant biology · 2026Article
- Genome-Wide Identification and Analysis of BAHD Acyltransferases Involved in Anthocyanin Biosynthesis inBiology · 2026Article
- Pharmacological effects, classification, genetic and molecular studies of different chemotypes essential oil ofJournal of pharmaceutical analysis · 2026Review
- From folklore to explore: integrating genomic and multiomics data forHorticulture research · 2026Article
- PfWRI1-10 transcription factor mediates lipid synthesis in Perilla frutescens through regulating PfBCCP1 gene transcription.BMC plant biology · 2026Article
- Development of a Purple-Leaf Perillene Chemotype Line inPlants (Basel, Switzerland) · 2026Article
- Identification and Validation of NAC Transcription Factors Enhancing Phenolic Acid Production inPlants (Basel, Switzerland) · 2026Article
- Unveiling Plant Metabolic Diversity: Integrating Metabolomics with Multi-Omics Approaches for Crop Improvement.Plants (Basel, Switzerland) · 2026Review
- One-Stone-Three-Birds Biomimetic Oral Targeting Delivery Strategy for On-Demand Controlled Drug Release and Intervertebral Disc Degeneration Therapy.Exploration (Beijing, China) · 2026Article
- CRISPR-Cas9 disruption of flavanone 3-hydroxylase produces a green phenotype and alters flavone metabolites in allotetraploid perilla.Frontiers in plant science · 2026Article
- Integrative analyses of metabolome and transcriptome reveal differences in terpenoids and identify the genes involved in the synthesis of terpenoids inFrontiers in plant science · 2026Article
- Development and application of SNP markers to discriminate Korean Perilla (Perilla frutescens) varieties using genomic sequence variations.Scientific reports · 2025Article
- Genome-wide association study to identification of candidate genes influencing key seed traits in Perilla frutescens.BMC plant biology · 2025Article
- Exploration of the Donors and Specific Genes of B Subgenome inPlants (Basel, Switzerland) · 2025Article
- Diploidization in a wild rice allopolyploid is both episodic and gradual.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Haplotype-resolved chromosome-level genome sequence of Elsholtzia splendens (Nakai ex F.Maek.).Scientific data · 2025Article
- Quantitative Comparison of Yield, Quality, and Metabolic Products of Different Medicinal Parts of Two Types ofPlants (Basel, Switzerland) · 2025Article
- Haplotype-resolved genome ofHorticulture research · 2025Article
Corrections and comments
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perilla is a young allotetraploid Lamiaceae species widely used in East Asia as herb and oil plant. Here, we report the high-quality, chromosome-scale genomes of the tetraploid (Perilla frutescens) and the AA diploid progenitor (Perilla citriodora). Comparative analyses suggest post Neolithic allotetraploidization within 10,000 years, and nucleotide mutation in tetraploid is 10% more than in diploid, both of which are dominated by G:C → A:T transitions. Incipient diploidization is characterized by balanced swaps of homeologous segments, and subsequent homeologous exchanges are enriched towards telomeres, with excess of replacements of AA genes by fractionated BB homeologs. Population analyses suggest that the crispa lines are close to the nascent tetraploid, and involvement of acyl-CoA: lysophosphatidylcholine acyltransferase gene for high α-linolenic acid content of seed oil is revealed by GWAS. These resources and findings provide insights into incipient diploidization and basis for breeding improvement of this medicinal plant.
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