Evidence map›Paper›PMID 34535640›Full record

ArticleCell death discovery2021

Axonal degeneration induces distinct patterns of phosphatidylserine and phosphatidylethanolamine externalization.

Hannah Faris, Mohammadali Almasieh, Leonard A Levin

Open access · goldAbstract read
In one paragraph

Article in Cell death discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hannah FarisDepartment of Ophthalmology and Visual Sciences, McGill University, Montreal, Canada.
Mohammadali AlmasiehDepartment of Ophthalmology and Visual Sciences, McGill University, Montreal, Canada.
Leonard A LevinDepartment of Ophthalmology and Visual Sciences, McGill University, Montreal, Canada. leonard.levin@mcgill.ca.ORCID http://orcid.org/0000-0002-1399-250X
McGill University · CA

Funding

Development of redox-active therapies for ischemic optic neuropathyR21EY025074 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI LEVIN, LEONARD A · 2015 to 2016
$421k
Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre) PJT-162396NEI NIH HHS R21 EY025074U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) R21EY025074
6 · The paper itself

Abstract

Axonal degeneration is a common feature of multiple neurodegenerative diseases, yet the mechanisms underlying its various manifestations are incompletely understood. We previously demonstrated that axonal degeneration is associated with externalization of phosphatidylserine (PS), which precedes morphological evidence of degeneration, is redox-sensitive, and is delayed in Wallerian degeneration slow (Wld

Identifiers

PMID34535640
PMCPMC8448818
OpenAlexW3199770540

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.