Evidence map›Paper›PMID 34535576›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

The PD-1 Regulatory Axis Inhibits T Cell-Independent B Cell Memory Generation and Reactivation.

M Ariel Spurrier, Jamie E Jennings-Gee, Christina A Daly, Karen M Haas

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Immune Checkpoints in B Cells: Unlocking New Potentials in Cancer Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

M Ariel SpurrierDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC.ORCID 0000-0002-3314-9683
Jamie E Jennings-GeeDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC.
Christina A DalyDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC.ORCID 0000-0001-7470-0454
Karen M HaasDepartment of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC kmhaas@wakehealth.edu.ORCID 0000-0002-9951-1964
Wake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
TRAINING PROGRAM IN IMMUNOLOGY AND PATHOGENESIST32AI007401 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Martha Ann Alexander-Miller · 1991 to 2026
$4.4M
Regulation of Memory B Cell Responses to Polysaccharide AntigensR01AI118876 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HAAS, KAREN M · 2015 to 2019
$1.9M
Developing effective adjuvants for native polysaccharide antigen-based vaccinesR21AI144758 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HAAS, KAREN M · 2019 to 2020
$419k
NCATS NIH HHS UL1 TR001420NCI NIH HHS P30 CA012197NIAID NIH HHS R01 AI118876NIAID NIH HHS R21 AI144758NIAID NIH HHS T32 AI007401
6 · The paper itself

Abstract

The inability of T cell-independent type 2 (TI-2) Ags to induce recall responses is a poorly understood facet of humoral immunity, yet critically important for improving vaccines. Using normal and V

Indexed as

AnimalsB7-H1 AntigenB-LymphocytesHomeostasisImmunity, HumoralImmunogenicity, VaccineImmunologic MemoryLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutPneumococcal InfectionsPneumococcal VaccinesProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 ReceptorProtein BindingB7-H1 AntigenPdcd1lg2 protein, mousePdcd1 protein, mousePneumococcal VaccinesProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 Receptor

Identifiers

PMID34535576
PMCPMC8492549
OpenAlexW3199078127

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.