Evidence map›Paper›PMID 34535544›Full record

ArticleRNA (New York, N.Y.)2021

DDX3X and DDX3Y are redundant in protein synthesis.

Srivats Venkataramanan, Margaret Gadek, Lorenzo Calviello, Kevin Wilkins, Stephen N Floor

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
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  6. Review
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  8. Article
  9. Article
  10. Article
  11. RNA helicase DDX3X promotes NK cell survival by supporting MCL1 expression.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Article
  12. Review
  13. Article
  14. AnBioengineering & translational medicine · 2025
    Article
  15. Article
  16. Article
  17. Diverse mechanisms of DDX3Y suppression by DDX3X.bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Srivats VenkataramananDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.ORCID 0000-0002-2507-401X
Margaret GadekDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.
Lorenzo CalvielloDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.ORCID 0000-0002-5600-0988
Kevin WilkinsDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.
Stephen N FloorDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California 94143, USA.ORCID 0000-0002-9965-9694
University of California, San Francisco · US

Funding

Investigating sex differences in DDX3X mouse modelsR01NS120667 · NINDS · DUKE UNIVERSITY · PI SILVER, DEBRA L. · 2021 to 2025
$3.4M
The impact of human RNA diversity on protein production and cell fateDP2GM132932 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLOOR, STEPHEN NICHOLAS · 2018 to 2018
$2.4M
Heterogenous cytoplasmic RNA-protein aggregates enhance cellular survival under stressF32GM133144 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VENKATARAMANAN, SRIVATS · 2020 to 2021
$111k
NIGMS NIH HHS DP2 GM132932NIGMS NIH HHS F32 GM133144NINDS NIH HHS R01 NS120667
6 · The paper itself

Abstract

DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X- and Y-linked paralogs

Indexed as

Protein BiosynthesisAmino Acid SequenceColonic NeoplasmsDEAD-box RNA HelicasesHCT116 CellsHumansMinor Histocompatibility AntigensSequence HomologyDDX3X protein, humanDDX3Y protein, humanDEAD-box RNA HelicasesMinor Histocompatibility AntigensDEAD-box proteinsRNAsex differencestranslational control

Identifiers

PMID34535544
PMCPMC8594478
OpenAlexW3200218762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.