Evidence map›Paper›PMID 34535473›Full record

ArticleBMJ open2021

Impact of pulse oximetry on hospital referral acceptance in children under 5 with severe pneumonia in rural Pakistan (district Jamshoro): protocol for a cluster randomised trial.

Fatima Mir, Apsara Ali Nathwani, Suhail Chanar, Amjad Hussain, Arjumand Rizvi, Imran Ahmed, Zahid Ali Memon, Atif Habib, Sajid Soofi, Zulfiqar Ahmed Bhutta

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03588377 (Impact of Pulse Oximetry on Hospital Referral Acceptance in Children Under 5 With Severe Pneumonia in District Jamshoro - A Cluster Randomized Trial -), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03588377 nacompletednot on this map

Impact of Pulse Oximetry on Hospital Referral Acceptance in Children Under 5 With Severe Pneumonia in District Jamshoro - A Cluster Randomized Trial - (GAPPD Scale up Project)

TypeinterventionalSponsorAga Khan UniversityRan2019 to 2020Enrolled543ConditionsSevere Pneumonia, HypoxemiaArmsPulse Oximetry
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fatima MirDepartment of Paediatrics & Child Health, Aga Khan University, Karachi, Sindh, Pakistan fatima.mir@aku.edu.ORCID 0000-0001-8602-5353
Apsara Ali NathwaniDepartment of Paediatrics & Child Health, Aga Khan University, Karachi, Sindh, Pakistan.ORCID 0000-0002-2899-1577
Suhail ChanarDepartment of Paediatrics & Child Health, Aga Khan University, Karachi, Sindh, Pakistan.ORCID 0000-0002-4087-1084
Amjad HussainDepartment of Paediatrics & Child Health, Aga Khan University, Karachi, Sindh, Pakistan.
Arjumand RizviDepartment of Paediatrics & Child Health, Aga Khan University, Karachi, Sindh, Pakistan.
Imran AhmedDepartment of Paediatrics & Child Health, Aga Khan University, Karachi, Sindh, Pakistan.
Zahid Ali MemonCentre of Excellence in Women and Child Health, Aga Khan University, Karachi, Sindh, Pakistan.
Atif HabibDepartment of Paediatrics & Child Health, Aga Khan University, Karachi, Sindh, Pakistan.
Sajid SoofiDepartment of Paediatrics & Child Health, Aga Khan University, Karachi, Sindh, Pakistan.ORCID 0000-0003-4192-8406
Zulfiqar Ahmed BhuttaDivision of Women and Child Health, Aga Khan University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPneumonia is a leading cause of death among children under 5 specifically in South Asia and sub-Saharan Africa. Hypoxaemia is a life-threatening complication among children under 5 with pneumonia. Hypoxaemia increases risk of mortality by 4.3 times in children with pneumonia than those without hypoxaemia. Prevalence of hypoxaemia varies with geography, altitude and severity (9%-39% Asia, 3%-10% African countries). In this protocol paper, we describe research methods for assessing impact of Lady Health Workers (LHWs) identifying hypoxaemia in children with signs of pneumonia during household visits on acceptance of hospital referral in district Jamshoro, Sindh. METHODS AND ANALYSIS: A cluster randomised controlled trial using pulse oximetry as intervention for children with severe pneumonia will be conducted in community settings. Children aged 0-59 months with signs of severe pneumonia will be recruited by LHWs during routine visits in both intervention and control arms after consent. Severe pneumonia will be defined as fast breathing and/or chest in-drawing, and, one or more danger sign and/or hypoxaemia (Sa02 <92%) in PO (intervention) group and fast breathing and/or chest in-drawing and one or more danger sign in clinical signs (control) group. Recruits in both groups will receive a stat dose of oral amoxicillin and referral to designated tertiary health facility. Analysis of variance will be used to compare baseline referral acceptance in both groups with that at end of study. ETHICS AND DISSEMINATION: Ethical approval was granted by the Ethics Review Committee of the Aga Khan University (4722-Ped-ERC-17), Karachi. Study results will be shared with relevant government and non-governmental organisations, presented at national and international research conferences and published in international peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER: NCT03588377.

Indexed as

PneumoniaAmoxicillinChildHumansOximetryPakistanRandomized Controlled Trials as TopicReferral and ConsultationAmoxicillinclinical trialspaediatric infectious disease & immunisationpublic healthrespiratory medicine (see thoracic medicine)

Identifiers

PMID34535473
PMCPMC8451312

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