Evidence map›Paper›PMID 34535471›Full record

Observational studyBMJ open2021

Association between tissue oxygenation and myocardial injury in patients undergoing major spine surgery: a prospective cohort study.

Katrine Feldballe Bernholm, Christian S Meyhoff, Philip Bickler

3 registry-linked trialsOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03518372 completednot on this map

Myocardial Injury and Intraoperative Tissue Oximetry in Patients Undergoing Spine Surgery (MONITOR)

Typeobservational_patient_registrySponsorUniversity of California, San FranciscoRan2018 to 2018Enrolled70ConditionsHypoxia, Myocardial Injury, Surgery--Complications
NCT07523321 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Moderate-to-severe Pain After Spinal Surgery: a Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled274ConditionsSpinal Surgery, Pain Intensity, Dexmedetomidine, EsketamineArmsCombined dexmedetomidine-esketamine administration, Placebo administration
NCT07525999 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Perioperative Use of Dexmedetomidine-esketamine Combination on Incidence of Chronic Postsurgical Pain After Spinal Surgery: a Randomized Controlled Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled274ConditionsSpinal Surgery, Pain Intensity, Dexmedetomidine, EsketamineArmsCombined dexmedetomidine-esketamine administration, Placebo administration
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Katrine Feldballe BernholmDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA bernholm3@hotmail.com.ORCID 0000-0001-5324-9430
Christian S MeyhoffDepartment of Anaesthesia and Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark.ORCID 0000-0002-4885-4609
Philip BicklerDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.ORCID 0000-0002-5077-4982
University of California, San Francisco · USUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the association between intraoperative tissue oxygenation and postoperative troponin elevation in patients undergoing major spine surgery. We hypothesised that a decrease in intraoperative skeletal muscle tissue oxygenation (SmO

designThis is a prospective cohort study.

settingSingle-centre, University of California San Francisco Medical Center.

participantsSeventy adult patients undergoing major elective spine surgery. PRIMARY AND SECONDARY OUTCOME MEASURES: High-sensitivity troponin T (hsTnT) was measured in plasma preoperatively and on the first and second day after surgery to assess the primary outcome of peak postoperative hsTnT. Secondary outcomes included MINS and intensive care unit (ICU) admission within 30 days. Skeletal cerebral tissue oxygenation and SmO

resultsMean age was 65 (33-85) years and 59% were female. No significant association was found between TW AUC for SmO

conclusionsDecrease in SmO TRIAL REGISTRATION NUMBER: NCT03518372.

Indexed as

Postoperative ComplicationsSpineAdultAgedElective Surgical ProceduresFemaleHumansPostoperative PeriodProspective StudiesTroponin TTroponin Tanaesthesia in orthopaedicsmyocardial infarctionspine

Identifiers

PMID34535471
PMCPMC8451303
OpenAlexW3200337353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.