Evidence map›Paper›PMID 34535103›Full record

ArticleBMC psychiatry2021

Post-traumatic stress disorder among persons with HIV who engage in heavy alcohol consumption in southwestern Uganda.

Allen Kekibiina, Julian Adong, Robin Fatch, Nneka I Emenyonu, Kara Marson, Brian Beesiga, Sara Lodi, Winnie R Muyindike, Moses Kamya, Gabriel Chamie and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Allen KekibiinaGlobal Health Collaborative, Mbarara University of Science and Technology, Mbarara, Uganda.
Julian AdongGlobal Health Collaborative, Mbarara University of Science and Technology, Mbarara, Uganda.
Robin FatchDepartment of Medicine, University of California, San Francisco, CA, USA.
Nneka I EmenyonuDepartment of Medicine, University of California, San Francisco, CA, USA.
Kara MarsonDepartment of Medicine, University of California, San Francisco, CA, USA.
Brian BeesigaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Sara LodiBoston University School of Public Health, Boston, MA, USA.
Winnie R MuyindikeGlobal Health Collaborative, Mbarara University of Science and Technology, Mbarara, Uganda.
Moses KamyaInfectious Diseases Research Collaboration (IDRC), Kampala, Uganda.
Gabriel ChamieDepartment of Medicine, University of California, San Francisco, CA, USA.
Michael G McDonellElson S Floyd College of Medicine, Washington State University, Spokane, WA, USA.
Judith A HahnDepartment of Medicine, University of California, San Francisco, CA, USA. Judy.Hahn@ucsf.edu.
University of California, San Francisco · USInfectious Diseases Research Collaboration · UGMbarara University of Science and Technology · UGBoston University · USGeorgia Highlands College · USMbarara National Referral Hospital · UG

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
Interventions to reduce alcohol use and increase adherence to TB preventive therapy among HIV/TB co-infected drinkers (DIPT 1/2)U01AA026223 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAHN, JUDITH ALISSA · 2017 to 2021
$2.8M
Interventions to reduce alcohol use and increase adherence to TB preventive therapy among HIV/TB co-infected drinkers (DIPT 2/2)U01AA026221 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAMIE, GABRIEL · 2017 to 2021
$2.7M
Training in Research Program on Alcohol Use by Persons with our at Risk for HIVK24AA022586 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAHN, JUDITH ALISSA · 2013 to 2023
$1.8M
NIAAA NIH HHS K24 AA022586NIAAA NIH HHS U01 AA026221NIAAA NIH HHS U01 AA026223NIAID NIH HHS P30 AI042853
6 · The paper itself

Abstract

backgroundWe aimed to describe the prevalence of PTSD symptoms and its associated factors in persons living with HIV (PLWH) in Uganda who engage in heavy alcohol use.

methodsWe analyzed baseline data from the Drinkers Intervention to Prevent Tuberculosis study which enrolls PLWH with latent tuberculosis who engage in heavy alcohol consumption. Using the primary care Post Traumatic Stress Disorder (PTSD) screening scale from the DSM-5 (PC-PTSD-5), probable PTSD was defined as reporting ≥3 of 5 assessed symptoms. We conducted the Alcohol Use Disorders Identification Test-Consumption and assessed demographics, smoking, symptoms of depression, and spirituality/religiosity.

resultsOf 421 participants enrolled from 2018 through 2020, the majority (68.2%) were male, median age was 40 years (interquartile range [IQR]: 32-47), and median AUDIT-C score was 6 [IQR: 4-8]. Half (50.1%) of the participants reported ever experiencing a traumatic event, and 20.7% reported ≥3 symptoms of PTSD. The most commonly reported PTSD symptoms in the past 1 month in the entire sample were avoidance (28.3%), nightmares (27.3%), and being constantly on guard (21.6%). In multivariable logistic regression analyses, level of alcohol use was not associated with probable PTSD (adjusted odds ratio [AOR] for each AUDIT-C point: (1.02; 95% CI: 0.92-1.14; p = 0.69); however, lifetime smoking (AOR 1.89; 95% CI: 1.10-3.24) and reporting symptoms of depression (AOR 1.89; 95% CI: 1.04-3.44) were independently associated with probable PTSD. CONCLUSIONS AND RECOMMENDATIONS: A history of traumatic events and probable PTSD were frequently reported among persons who engage in heavy drinking, living with HIV in Uganda. Level of alcohol use was not associated with probable PTSD in this sample of PLWH with heavy alcohol use, however other behavioral and mental health factors were associated with probable PTSD. These data highlight the high prevalence of PTSD in this group, and the need for screening and interventions for PTSD and mental health problems.

Indexed as

AlcoholismHIV InfectionsStress Disorders, Post-TraumaticAdultAlcohol DrinkingFemaleHumansMaleUgandaAlcoholHIVPost-traumatic stress disorder (PTSD)Uganda

Identifiers

PMID34535103
PMCPMC8449437
OpenAlexW3199676272

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.