ArticleComputers in biology and medicine2021
Single-level subject-specific finite element model can predict fracture outcomes in three-level spine segments under different loading rates.
Article in Computers in biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Viscoelastic Modeling for Failure Analysis of Human Vertebral Bone Undergoing Quasi-Static and Dynamic Compression.Bioengineering (Basel, Switzerland) · 2026Article
- Beyond SINS: A Critical Review of Biomechanical, Microstructural, and Radiomic Biomarkers for Predicting Fracture Risk in Spinal Metastases.Diagnostics (Basel, Switzerland) · 2026Review
- Optimization of Bone Cement Stiffness in Metastatic Vertebral Augmentation: Balancing Strength Restoration and Stress Redistribution.Annals of biomedical engineering · 2026Article
- Computational Assessment of Fracture Risk in Vertebral Bodies With Simulated Defects: The Role of Baseline Strength and Tumor Size.International journal for numerical methods in biomedical engineering · 2025Article
- Prediction of vertebral failure under general loadings of compression, flexion, extension, and side-bending.Journal of the mechanical behavior of biomedical materials · 2025Article
- Subject-Specific Geometry of FE Lumbar Spine Models for the Replication of Fracture Locations Using Dynamic Drop Tests.Annals of biomedical engineering · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Osteoporosis-related vertebral compression fracture can occur under normal physiological activities. Bone metastasis is another source of vertebral fracture. Different loading rates, either high-energy traumas such as falls or low-energy traumas under normal physiological activities, can result in different fracture outcomes. The aim of the current study was to develop a quantitative computed tomography-based finite element analysis (QCT/FEA) technique for single vertebral bodies to predict fracture strength of three-level spine segments. Developed QCT/FEA technique was also used to characterize vertebral elastic moduli at two loading rates of 5 mm/min, representing a physiologic loading condition, and 12000 mm/min, representing a high-energy trauma. To this end, a cohort of human spine segments divided into three groups of intact, defect, and augmented were mechanically tested to fracture; then, experimental stiffness and fracture strength values were measured. Outcomes of this study showed no significant difference between the elastic modulus equations at the two testing speeds. Areal bone mineral density measured by dual x-ray absorptiometry (DXA/BMD) explained only 53% variability (R
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