Evidence map›Paper›PMID 34534695›Full record

ReviewMicrobes and infection2022

Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals.

Emmanuel Sunday Okeke, Martins Obinna Ogugofor, Ndidi Ethel Nkwoemeka, Ekene John Nweze, Charles Obinwanne Okoye

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microbes and infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Essential Oils and Melatonin as Functional Ingredients in Dogs.Animals : an open access journal from MDPI · 2022
    Review
  4. Article
  5. Melatonin inMolecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Emmanuel Sunday OkekeDepartment of Biochemistry, University of Nigeria, Nsukka, 41000, Enugu State, Nigeria; Natural Science Unit, SGS, University of Nigeria, Nsukka, 41000, Enugu State, Nigeria; School of Environment and Safety Engineering, Jiangsu University, 212013, PR China; Organization of African Academic Doctors (OAAD), Off Kamiti Road, 25305000100, Nairobi, Kenya.
Martins Obinna OgugoforDepartment of Biochemistry, University of Nigeria, Nsukka, 41000, Enugu State, Nigeria; Department of Chemical Sciences, Coal City University, Enugu, Enugu State, Nigeria.
Ndidi Ethel NkwoemekaNatural Science Unit, SGS, University of Nigeria, Nsukka, 41000, Enugu State, Nigeria; Department of Microbiology, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria.
Ekene John NwezeDepartment of Biochemistry, University of Nigeria, Nsukka, 41000, Enugu State, Nigeria.
Charles Obinwanne OkoyeSchool of Environment and Safety Engineering, Jiangsu University, 212013, PR China; Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria; Biofuels Institute, Jiangsu University, Zhenjiang, 212013, PR China; Organization of African Academic Doctors (OAAD), Off Kamiti Road, 25305000100, Nairobi, Kenya. Electronic address: charles.okoye@unn.edu.ng.
University of Nigeria · NGJiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phytomelatonin is a pleiotropic molecule that originated in higher plants with many diverse actions and is primarily an antioxidant. The recent identification and advancement of phytomelatonin unraveled the potential of this modulatory molecule being considered a new plant hormone, suggesting its relevance in treating respiratory infections, including COVID-19. Besides, this molecule is also involved in multiple hormonal, physiological, and biological processes at different levels of cell organization and has been marked for its ability to cross the blood-brain barrier and prominent antioxidant effects, reducing mitochondrial electron leakage, up-regulating antioxidant enzymes, acting as a free radical scavenger, and interfering with pro-inflammatory signaling pathways as seen in mood swings, body temperature, sleep, cancer, cardiac rhythms, and immunological regulation modulators. However, due to its diversity, availability, affordability, convenience, and high safety profile, phytomelatonin has also been suggested as a natural adjuvant. This review discussed the origin, content in various plant species, processes of extraction, and detection and therapeutic potentials of phytomelatonin in treating COVID-19-exposed individuals.

Indexed as

COVID-19MelatoninAntioxidantsHumansPlant Growth RegulatorsSARS-CoV-2AntioxidantsMelatoninPlant Growth RegulatorsAnti-inflammatoryAntioxidantCOVID-19-exposed individualsPhytomelatoninPhytotherapeutic

Identifiers

PMID34534695
PMCPMC8440003
OpenAlexW3199096627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.