Evidence map›Paper›PMID 34534661›Full record

ReviewOsteoarthritis and cartilage2022

Epidemiology of osteoarthritis.

K D Allen, L M Thoma, Y M Golightly

4 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoarthritis and cartilage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 441 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
441citing papers in PubMed, 15 pooled it
90.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06906094 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Prevention of Post mEniscectomy Osteoarthritis: From New Animal Model to Patient pRofiLing (PEARL)

TypeobservationalSponsorIstituto Clinico HumanitasRan2024 to 2025Enrolled100ConditionsMeniscopathyArmsSelective meniscectomy
NCT07122154 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Future Osteoarthritis Treatment (FOOTSTEP) - Free Open Online Course for All

TypeobservationalSponsorEva Ekvall-HanssonRan2025 to 2026Enrolled50ConditionsOsteoarthritis (OA)
NCT07243392 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Comparative Study on Effects of Steroid, Dextrose Prolotherapy, and Platelet-Rich Plasma Injections to Lessen Pain in Knee Osteoarthritis Patients

TypeinterventionalSponsorLincoln University CollegeRan2025 to 2026Enrolled72ConditionsKnee OsteoarthritisArmsIntra articular steroid injection, Intra articular PRP, Intra articular dextrose prolotherapy
NCT07313020 early_phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

A Visualization Clinical Study Using a Handheld MPI Imaging Device for Monitoring Mesenchymal Stromal Cells in Osteoarthritis Treatment

TypeinterventionalSponsorSoochow UniversityRan2025 to 2026Enrolled10ConditionsKnee Arthritis OsteoarthritisArmsHuman Umbilical Cord-derived Mesenchymal Stromal Cells (hUC-MSCs), Ferumoxytol (SPIO) Solution for Injection (Placebo)
3 · Its place in the literature

Who cites it

441 citing papers in PubMed, 15 syntheses or guidelines pooled it, 866 citations in OpenAlex.

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381 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

K D AllenThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Center for Health Services Research in Primary Care, Department of Veterans Affairs Medical Center, Durham, NC, USA. Electronic address: kdallen@email.unc.edu.
L M ThomaThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Physical Therapy, Department of Allied Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Y M GolightlyThurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Physical Therapy, Department of Allied Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · US

Funding

UNC Core Center for Clinical ResearchP30AR072580 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEIGH Fleming CALLAHAN, Amanda E Nelson · 2019 to 2026
$6.1M
HSRD VA IK6 HX002838NIAMS NIH HHS P30 AR072580
6 · The paper itself

Abstract

objectiveTo summarize the current state of the evidence regarding osteoarthritis (OA) prevalence, incidence and risk factors at the person-level and joint-level.

designThis was a narrative review that took a comprehensive approach regarding inclusion of potential risk factors. The review complements prior reviews of OA epidemiology, with a focus on new research and emerging topics since 2017, as well as seminal studies.

resultsStudies continue to illustrate the high prevalence of OA worldwide, with a greater burden among older individuals, women, some racial and ethnic groups, and individuals with lower socioeconomic status. Modifiable risk factors for OA with the strongest evidence are obesity and joint injury. Topics of high interest or emerging evidence for a potential association with OA risk or progression include specific vitamins and diets, high blood pressure, genetic factors, metformin use, bone mineral density, abnormal joint shape and malalignment, and lower muscle strength/quality. Studies also continue to highlight the heterogenous nature of OA, with strong interest in understanding and defining OA phenotypes.

conclusionsOA is an increasingly prevalent condition with worldwide impacts on many health outcomes. The strong evidence for obesity and joint injury as OA risk factors calls for heightened efforts to mitigate these risks at clinical and public health levels. There is also a need for continued research regarding how potential person- and joint-level risk factors may interact to influence the development and progression of OA.

Indexed as

HumansIncidenceOsteoarthritisPrevalenceRisk FactorsEpidemiologyOsteoarthritisRisk factors

Identifiers

PMID34534661
PMCPMC10735233
OpenAlexW3200982465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.