Evidence map›Paper›PMID 34534447›Full record

ArticleStem cell reports2021

Tetraspanin CD82 regulates S1PR

Chelsea A Saito-Reis, Victoria D Balise, Erica M Pascetti, Magdalena Jiminez, Jennifer M Gillette

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Regulation of CXCR4 function by S1PCell communication and signaling : CCS · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. The dual role of p63 in cancer.Frontiers in oncology · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chelsea A Saito-ReisDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Victoria D BaliseDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Erica M PascettiDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Magdalena JiminezDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA.
Jennifer M GilletteDepartment of Pathology, University of New Mexico Health Science Center, Albuquerque, NM, USA; University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA. Electronic address: jgillette@salud.unm.edu.
University of New Mexico · US

Funding

NM-INBRE Sequencing and Bioinformatics CoreP20GM103451 · NIGMS · NEW MEXICO STATE UNIVERSITY LAS CRUCES · PI SHELLEY LUSETTI · 2012 to 2026
$61.2M
WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
FAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4M
MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM (T32)T32HL007736 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI RESTA, THOMAS C · 1993 to 2025
$6.5M
Functional Role of Tetraspanin CD82 in Hematopoietic Stem Cell InteractionsR01HL122483 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jennifer Gillette · 2015 to 2026
$4.2M
NCI NIH HHS P30 CA118100NHLBI NIH HHS R01 HL122483NHLBI NIH HHS T32 HL007736NIGMS NIH HHS K12 GM088021NIGMS NIH HHS P20 GM103451
6 · The paper itself

Abstract

Hematopoietic stem and progenitor cell (HSPC) mobilization into the blood occurs under normal physiological conditions and is stimulated in the clinic to enable the isolation of HSPCs for transplantation therapies. In the present study, we identify the tetraspanin CD82 as a novel regulator of HSPC mobilization. Using a global CD82 knockout (CD82KO) mouse, we measure enhanced HSPC mobilization after granulocyte-colony stimulating factor (G-CSF) or AMD3100 treatment, which we find is promoted by increased surface expression of the sphingosine 1-phosphate receptor 1 (S1PR

Indexed as

Hematopoietic Stem Cell MobilizationAnimalsAntigens, CD34Gene Expression RegulationGranulocyte Colony-Stimulating FactorHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansKangai-1 ProteinMiceMice, Inbred C57BLMice, KnockoutSignal TransductionSphingosine-1-Phosphate ReceptorsStem CellsTetraspaninsAntigens, CD34Cd82 antigen, mouseGranulocyte Colony-Stimulating FactorKangai-1 ProteinS1pr1 protein, mouseSphingosine-1-Phosphate ReceptorsTetraspaninsCD82hematopoietic stem and progenitor cellsmobilizationsphingosine-1-phosphate receptortetraspanins

Identifiers

PMID34534447
PMCPMC8514849
OpenAlexW3201154007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.