ArticleAngewandte Chemie (International ed. in English)2021
Parahydrogen Hyperpolarization Allows Direct NMR Detection of α-Amino Acids in Complex (Bio)mixtures.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Mixture Analysis at Micromolar Concentrations with 2D Benchtop NMR Enhanced by SABRE Hyperpolarization.Analytical chemistry · 2026Article
- Article
- Rapid RASER MRI.Angewandte Chemie (International ed. in English) · 2026Article
- Benchtop NMR signal enhancement of metabolites in urine extract using SABRE.Chemical communications (Cambridge, England) · 2026Article
- Semi-Targeted Nuclear Magnetic Resonance Metabolomics via Parahydrogen-Induced Hyperpolarization for Enhanced Sensitivity to Metabolic Composition.Journal of the American Chemical Society · 2025Article
- d-amino acids: new functional insights.The FEBS journal · 2025Review
- Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes.ACS catalysis · 2025Review
- Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications.Analysis & sensing · 2025Article
- Parahydrogen Polarization in Reverse Micelles and Application to Sensing of Protein-Ligand Binding.Journal of the American Chemical Society · 2024Article
- Bullet-DNP Enables NMR Spectroscopy of Pyruvate and Amino Acids at Nanomolar to Low Micromolar Concentrations.Analytical chemistry · 2024Article
- Overhauser enhanced liquid state nuclear magnetic resonance spectroscopy in one and two dimensions.Nature communications · 2024Article
- Hyperpolarization-Enhanced NMR Spectroscopy of Unaltered Biofluids Using Photo-CIDNP.Analytical chemistry · 2024Article
- Reversible Parahydrogen Induced Hyperpolarization ofAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Parahydrogen in Reversible Exchange Induces Long-LivedAnalytical chemistry · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- NMR Discrimination of d- and l-α-Amino Acids at Submicromolar Concentration via Parahydrogen-Induced Hyperpolarization.Journal of the American Chemical Society · 2023Article
- NMR methods for the analysis of mixtures.Chemical communications (Cambridge, England) · 2022Review
- Selective Isotope Labeling and LC-Photo-CIDNP Enable NMR Spectroscopy at Low-Nanomolar Concentration.Journal of the American Chemical Society · 2022Article
- Analysis of Complex Mixtures by Chemosensing NMR UsingAccounts of chemical research · 2022Article
- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications.Chemical science · 2022Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The scope of non-hydrogenative parahydrogen hyperpolarization (nhPHIP) techniques has been expanding over the last years, with the continuous addition of important classes of substrates. For example, pyruvate can now be hyperpolarized using the Signal Amplification By Reversible Exchange (SABRE) technique, offering a fast, efficient and low-cost PHIP alternative to Dynamic Nuclear Polarization for metabolic imaging studies. Still, important biomolecules such as amino acids have so far resisted PHIP, unless properly functionalized. Here, we report on an approach to nhPHIP for unmodified α-amino acids that allows their detection and quantification in complex mixtures at sub-micromolar concentrations. This method was tested on human urine, in which natural α-amino acids could be measured after dilution with methanol without any additional sample treatment.
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