ArticleMicrobial biotechnology2022
Bridging the gap between microbial limits and extremes in space: space microbial biotechnology in the next 15 years.
Article in Microbial biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Microgravity-induced constraints on melanin bioproduction: investigating E. coli metabolic responses aboard the international space station.NPJ microgravity · 2026Article
- Emerging Chemical and Biological Materials Technologies in the Extraplanetary Environment.Nano-micro letters · 2026Review
- Proteomics of long-term acclimation of the desert cyanobacteriumCurrent research in microbial sciences · 2026Article
- Co-expression of environmental extremophilic genes strongly enhances Escherichia coli cross-protection to abiotic stress.Extremophiles : life under extreme conditions · 2025Article
- Synthetic biology for space exploration.NPJ microgravity · 2025Review
- Developing an alternative medium for in-space biomanufacturing.Nature communications · 2025Article
- Building Synthetic Cells─From the Technology Infrastructure to Cellular Entities.ACS synthetic biology · 2024Review
- Polyextremophile engineering: a review of organisms that push the limits of life.Frontiers in microbiology · 2024Review
- Microbial biomanufacturing for space-exploration-what to take and when to make.Nature communications · 2023Review
- Toward sustainable space exploration: a roadmap for harnessing the power of microorganisms.Nature communications · 2023Review
- Enabling deep-space experimentations on cyanobacteria by monitoring cell division resumption in driedFrontiers in microbiology · 2023Article
- Absence of increased genomic variants in the cyanobacterium Chroococcidiopsis exposed to Mars-like conditions outside the space station.Scientific reports · 2022Article
- The smallest space miners: principles of space biomining.Extremophiles : life under extreme conditions · 2022Review
- Bridging the gap between microbial limits and extremes in space: space microbial biotechnology in the next 15 years.Microbial biotechnology · 2022Article
- Database of space life investigations and bioinformatics of microbiology in extreme environments.Frontiers in microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The establishment of a permanent human settlement in space is one of humanity's ambitions. To achieve this, microorganisms will be used to carry out many functions such as recycling, food and pharmaceutical production, mining and other processes. However, the physical and chemical extremes in all locations beyond Earth exceed known growth limits of microbial life. Making microbes more tolerant of a greater range of extraterrestrial extremes will not produce organisms that can grow in unmodified extraterrestrial environments since in many of them not even liquid water can exist. However, by narrowing the gap, the engineering demands on bioindustrial processes can be reduced and greater robustness can be incorporated into the biological component. I identify and describe these required microbial biotechnological modifications and speculate on long-term possibilities such as microbial biotechnology on Saturn's moon Titan to support a human presence in the outer Solar System and bioprocessing of asteroids. A challenge for space microbial biotechnology in the coming decades is to narrow the microbial gap by systemically identifying the genes required to do this and incorporating them into microbial systems that can be used to carry out bioindustrial processes of interest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.