Evidence map›Paper›PMID 34534333›Full record

SynthesisJournal of neuropathology and experimental neurology2021

Histological Findings After Aortic Cross-Clamping in Preclinical Animal Models.

Hamdy Awad, Alexander Efanov, Jayanth Rajan, Andrew Denney, Bradley Gigax, Peter Kobalka, Hesham Kelani, D Michele Basso, John Bozinovski, Esmerina Tili

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neuropathology and experimental neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Aortic cross-clamping, resection, and end-to-end anastomosis in a dog presenting with rib osteosarcoma.The Canadian veterinary journal = La revue veterinaire canadienne · 2025
    Article
  4. MicroRNAFrontiers in molecular neuroscience · 2022
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hamdy AwadFrom the Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Alexander EfanovFrom the Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Jayanth RajanFrom the Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Andrew DenneyFrom the Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Bradley GigaxFrom the Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Peter KobalkaDepartment of Pathology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Hesham KelaniFrom the Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
D Michele BassoDepartment of Neuroscience, School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, Ohio, USA.
John BozinovskiDivision of Cardiac Surgery, Department of Surgery, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
Esmerina TiliFrom the Department of Anesthesiology, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.
The Ohio State University Wexner Medical Center · USThe Ohio State University · US

Funding

Behavioral and Cellular Determinants of Treadmill Training and Recovery After SCIR01NS074882 · NINDS · OHIO STATE UNIVERSITY · PI BASSO, D M · 2011 to 2020
$3.3M
Identifying effective therapies to prevent paralysis after aortic aneurysm repair surgeryR21NS113097 · NINDS · OHIO STATE UNIVERSITY · PI ELSAYED-AWAD, HAMDY M., TILI, ESMERINA · 2019 to 2019
$429k
Elucidating the role of miR-155 in the development of paralysis consecutive to spinal cord damage caused by thoracic-abdominal aortic aneurysm repair surgeryR03NS102861 · NINDS · OHIO STATE UNIVERSITY · PI TILI, ESMERINA · 2017 to 2018
$156k
NINDS NIH HHS R01 NS074882NINDS NIH HHS R03 NS102861NINDS NIH HHS R21 NS113097
6 · The paper itself

Abstract

Spinal cord ischemic injury and paralysis are devastating complications after open surgical repair of thoracoabdominal aortic aneurysms. Preclinical models have been developed to simulate the clinical paradigm to better understand the neuropathophysiology and develop therapeutic treatment. Neuropathological findings in the preclinical models have not been comprehensively examined before. This systematic review studies the past 40 years of the histological findings after open surgical repair in preclinical models. Our main finding is that damage is predominantly in the grey matter of the spinal cord, although white matter damage in the spinal cord is also reported. Future research needs to examine the neuropathological findings in preclinical models after endovascular repair, a newer type of surgical repair used to treat aortic aneurysms.

Indexed as

Disease Models, AnimalAnimalsAortic Aneurysm, AbdominalConstrictionDogsGray MatterHumansMicePapioRabbitsRatsReperfusion InjurySheepSpecies SpecificitySpinal CordSpinal Cord InjuriesAortic aneurysmCross-clampingHistologyIschemiaNeuropathologySpinal cord

Identifiers

PMID34534333
PMCPMC8783616
OpenAlexW3199822893

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.