Evidence map›Paper›PMID 34534327›Full record

Observational studyThe Journal of clinical endocrinology and metabolism2022

Low-Iodine Diet of 4 Days Is Sufficient Preparation for 131I Therapy in Differentiated Thyroid Cancer Patients.

Bernadette L Dekker, Mirthe H Links, Anneke C Muller Kobold, Linda G Swart-Busscher, Marleen Kars, Judith A P Bons, Adrienne H Brouwers, Thera P Links, Anouk N A van der Horst-Schrivers

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Bernadette L DekkerUniversity of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, 9700 RB Groningen, the Netherlands.ORCID 0000-0002-4785-9723
Mirthe H LinksUniversity of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, 9700 RB Groningen, the Netherlands.
Anneke C Muller KoboldUniversity of Groningen, University Medical Center Groningen, Department of Laboratory Medicine, 9700 RB Groningen, the Netherlands.ORCID 0000-0003-3457-4179
Linda G Swart-BusscherUniversity of Groningen, University Medical Center Groningen, Department of Paramedical Sciences, 9700 RB Groningen, the Netherlands.
Marleen KarsDepartment of Internal Medicine, Division of Endocrinology, Maastricht University Medical Center, 6202 AZ, Maastricht, the Netherlands.
Judith A P BonsCentral Diagnostic Laboratory, Maastricht University Medical Center, 6202 AZ, Maastricht, the Netherlands.
Adrienne H BrouwersUniversity of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, 9700 RB Groningen, the Netherlands.ORCID 0000-0003-2698-1516
Thera P LinksUniversity of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, 9700 RB Groningen, the Netherlands.ORCID 0000-0001-5327-1718
Anouk N A van der Horst-SchriversUniversity of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, 9700 RB Groningen, the Netherlands.ORCID 0000-0002-1181-5032
University Medical Center Groningen · NLUniversity Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextNo consensus exists about the optimal duration of the low-iodine diet (LID) in the preparation of 131I therapy in differentiated thyroid cancer (DTC) patients.

objectiveThis work aimed to investigate if a LID of 4 days is enough to achieve adequate iodine depletion in preparation for 131I therapy. In addition, the nutritional status of the LID was evaluated.

methodsIn this prospective study, 65 DTC patients treated at 2 university medical centers were included between 2018 and 2021. The patients collected 24-hour urine on days 4 and 7 of the LID and kept a food diary before and during the LID. The primary outcome was the difference between the 24-hour urinary iodine excretion (UIE) on both days.

resultsThe median 24-hour UIE on days 4 and 7 of the LID were not significantly different (36.1 mcg [interquartile range, 25.4-51.2 mcg] and 36.5 mcg [interquartile range, 23.9-47.7 mcg], respectively, P = .43). On day 4 of the LID, 72.1% of the DTC patients were adequately prepared (24-hour UIE < 50 mcg), and 82.0% of the DTC patients on day 7 (P = .18). Compared to the self-reported regular diet, DTC patients showed a significantly (P < .01) lower percentage of nutrient intake (calories, protein, calcium, iodine, and water) during the LID.

conclusionThe 24-hour UIE on day 4 of the LID did not differ from day 7, and therefore shortening the LID from 7 to 4 days seems justified to prepare DTC patients for 131I therapy in areas with sufficient iodine intake and may be beneficial to maintain a sufficient nutritional intake during DTC treatment.

Indexed as

DietAdultAgedDiet RecordsFemaleHumansIodineIodine RadioisotopesMaleMiddle AgedNutritional StatusProspective StudiesThyroid NeoplasmsTrace ElementsIodineIodine-131Iodine RadioisotopesTrace Elementsindividual perceptionsiodine intakelow-iodine dietnutrition diaryradioactive iodine therapyurinary iodine excretion

Identifiers

PMID34534327
PMCPMC8764339
OpenAlexW3201507263

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.