ArticleBrain : a journal of neurology2021
Changes in the language system as amyloid-β accumulates.
Article in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- The electrophysiological basis of resting-state fMRI hyperconnectivity in early Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Language impairment as a risk factor for dementia conversion in parkinson's disease with mild cognitive impairment: a quantitative EEG study.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Early aperiodic EEG changes in preclinical and prodromal Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Proteins Associated with Cognition in Amyloid-beta Positive Elders Based on Cerebrospinal Fluid Proteomics.Molecular neurobiology · 2025Article
- Development of language composites for enhanced sensitivity to multiple plasma biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Plasma vesicle-associated membrane protein 2 and glial fibrillary acidic protein associate with synaptic density in older adults without dementia.Brain communications · 2025Article
- EEG-based graph network analysis in relation to regional tau in asymptomatic Alzheimer's disease.Brain communications · 2025Article
- Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET.Brain communications · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Alteration of functional connectivity network in population of objectively-defined subtle cognitive decline.Brain communications · 2024Article
- Language dysfunction correlates with cognitive impairments in older adults without dementia mediated by amyloid pathology.Frontiers in neurology · 2023Article
- Classification ofEuropean journal of nuclear medicine and molecular imaging · 2022Article
- Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease.Cell reports · 2022Article
- Phospho-specific plasma p-tau181 assay detects clinical as well as asymptomatic Alzheimer's disease.Annals of clinical and translational neurology · 2022Article
- Plasma GFAP and language-network tau mediate the effect of amyloid burden on semantic fluency: A mediation analysis.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Language dysfunction is common in Alzheimer's disease. There is increasing interest in the preclinical or asymptomatic phase of Alzheimer's disease. Here we examined in 35 cognitively intact older adults (age range 52-78 years at baseline, 17 male) in a longitudinal study design the association between accumulation of amyloid over a 5-6-year period, measured using PET, and functional changes in the language network measured over the same time period using task-related functional MRI. In the same participants, we also determined the association between the longitudinal functional MRI changes and a cross-sectional measure of tau load as measured with 18F-AV1451 PET. As predicted, the principal change occurred in posterior temporal cortex. In the cortex surrounding the right superior temporal sulcus, the response amplitude during the associative-semantic versus visuo-perceptual task increased over time as amyloid load accumulated (Pcorrected = 0.008). In a whole-brain voxel-wise analysis, amyloid accumulation was also associated with a decrease in response amplitude in the left inferior frontal sulcus (Pcorrected = 0.009) and the right dorsomedial prefrontal cortex (Pcorrected = 0.005). In cognitively intact older adults, cross-sectional tau load was not associated with longitudinal changes in functional MRI response amplitude. Our findings confirm the central role of the neocortex surrounding the posterior superior temporal sulcus as the area of predilection within the language network in the earliest stages of Alzheimer's disease. Amyloid accumulation has an impact on cognitive brain circuitry in the asymptomatic phase of Alzheimer's disease.
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