Evidence map›Paper›PMID 34534215›Full record

SynthesisPLoS medicine2021

Differences in outcomes of mandatory motorcycle helmet legislation by country income level: A systematic review and meta-analysis.

Jacob R Lepard, Riccardo Spagiari, Jacquelyn Corley, Ernest J Barthélemy, Eliana Kim, Rolvix Patterson, Sara Venturini, Megan E H Still, Yu Tung Lo, Gail Rosseau and 2 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in PLoS medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. [Injury and death in motorcyclists: Umbrella review].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Pooled it
  2. Motorcycle injuries: a systematic review for forensic evaluation.International journal of legal medicine · 2024
    Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Review
  7. Article
  8. Measurement of the Burden of Road Injuries in Colombia, 1990-2021.International journal of environmental research and public health · 2025
    Observational
  9. Article
  10. Article
  11. Article
  12. Effectiveness of a helmet promotion campaign, China.Bulletin of the World Health Organization · 2022
    Article
  13. Outcome of head injury in motorbike riders.Pakistan journal of medical sciences
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jacob R LepardDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.ORCID 0000-0002-9690-4113
Riccardo SpagiariHumanitas University, Milano, Italy.ORCID 0000-0001-6069-7514
Jacquelyn CorleyProgram in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.
Ernest J BarthélemyProgram in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.ORCID 0000-0002-4001-9342
Eliana KimProgram in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.ORCID 0000-0003-1241-2072
Rolvix PattersonProgram in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.ORCID 0000-0001-7004-615X
Sara VenturiniAberdeen Royal Infirmary, Aberdeen, Scotland, United Kingdom.ORCID 0000-0002-9541-0090
Megan E H StillDepartment of Neurosurgery, University of Florida, Gainesville, Florida, United States of America.ORCID 0000-0002-7665-2692
Yu Tung LoDepartment of Neurosurgery, National Neuroscience Institute, Singapore.ORCID 0000-0002-4234-8991
Gail RosseauDepartment of Neurosurgery, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America.
Rania A MekaryComputational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
Kee B ParkProgram in Global Surgery and Social Change, Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recent Lancet Commission on Legal Determinants of Global Health argues that governance can provide the framework for achieving sustainable development goals. Even though over 90% of fatal road traffic injuries occur in low- and middle-income countries (LMICs) primarily affecting motorcyclists, the utility of helmet laws outside of high-income settings has not been well characterized. We sought to evaluate the differences in outcomes of mandatory motorcycle helmet legislation and determine whether these varied across country income levels. METHODS AND

findingsA systematic review and meta-analysis were completed using the PRISMA checklist. A search for relevant articles was conducted using the PubMed, Embase, and Web of Science databases from January 1, 1990 to August 8, 2021. Studies were included if they evaluated helmet usage, mortality from motorcycle crash, or traumatic brain injury (TBI) incidence, with and without enactment of a mandatory helmet law as the intervention. The Newcastle-Ottawa Scale (NOS) was used to rate study quality and funnel plots, and Begg's and Egger's tests were used to assess for small study bias. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were stratified by high-income countries (HICs) versus LMICs using the random-effects model. Twenty-five articles were included in the final analysis encompassing a total study population of 31,949,418 people. There were 17 retrospective cohort studies, 2 prospective cohort studies, 1 case-control study, and 5 pre-post design studies. There were 16 studies from HICs and 9 from LMICs. The median NOS score was 6 with a range of 4 to 9. All studies demonstrated higher odds of helmet usage after implementation of helmet law; however, the results were statistically significantly greater in HICs (OR: 53.5; 95% CI: 28.4; 100.7) than in LMICs (OR: 4.82; 95% CI: 3.58; 6.49), p-value comparing both strata < 0.0001. There were significantly lower odds of motorcycle fatalities after enactment of helmet legislation (OR: 0.71; 95% CI: 0.61; 0.83) with no significant difference by income classification, p-value: 0.27. Odds of TBI were statistically significantly lower in HICs (OR: 0.61, 95% CI 0.54 to 0.69) than in LMICs (0.79, 95% CI 0.72 to 0.86) after enactment of law (p-value: 0.0001). Limitations of this study include variability in the methodologies and data sources in the studies included in the meta-analysis as well as the lack of available literature from the lowest income countries or from the African WHO region, in which helmet laws are least commonly present.

conclusionsIn this study, we observed that mandatory helmet laws had substantial public health benefits in all income contexts, but some outcomes were diminished in LMIC settings where additional measures such as public education and law enforcement might play critical roles.

Indexed as

Head Protective DevicesIncomeLaw EnforcementAccidents, TrafficCraniocerebral TraumaDeveloping CountriesGlobal HealthHumansMotorcyclesPolicy MakingProtective FactorsRisk AssessmentRisk Factors

Identifiers

PMID34534215
PMCPMC8486090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.