ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2022
Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Ultrasound-Mediated Thrombolysis: From Mechanistic Insights to Advanced Nanoplatforms and Clinical Translation.Advanced healthcare materials · 2026Review
- Passive cavitation imaging with pMedical physics · 2026Article
- Histotripsy-mediated reactive oxygen species generation in vitro.Ultrasonics · 2026Article
- Self-Sensing with Hollow Cylindrical Transducers for Histotripsy-Enhanced Aspiration Mechanical Thrombectomy Applications.Sensors (Basel, Switzerland) · 2025Article
- Enhancing Passive Cavitation Imaging Using pIEEE transactions on bio-medical engineering · 2025Article
- Assessment of Catheter-Directed Thrombolysis and Histotripsy Treatment for Deep Vein Thrombosis.Journal of vascular and interventional radiology : JVIR · 2025Article
- xDDx: A Numerical Toolbox for Ultrasound Transducer Characterization and Design With Acoustic Holography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- A 9-Fr Endovascular Therapy Transducer With an Acoustic Metamaterial Lens for Rapid Stroke Thrombectomy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2024Article
- Histotripsy and Catheter-Directed Lytic: Efficacy in Highly Retracted Porcine Clots In Vitro.Ultrasound in medicine & biology · 2024Article
- Contrast-Enhanced Imaging of Histotripsy Bubble Clouds Using Chirp-Coded Excitation and Volterra Filtering.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Research progress and clinical evaluation of histotripsy: a narrative review.Annals of translational medicine · 2023Review
- Article
- Assessment of bubble activity generated by histotripsy combined with echogenic liposomes.Physics in medicine and biology · 2022Article
- (More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy.PloS one · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Chronic thrombi of the deep veins of the leg are resistant to dissolution or removal by current interventions and can act as thrombogenic sources. Histotripsy, a focused ultrasound therapy, uses the mechanical activity of bubble clouds to liquefy target tissues. In vitro experiments have shown that histotripsy enhances thrombolytic agent recombinant tissue plasminogen activator in a highly retracted clot model resistant to lytic therapy alone. Although these results are promising, further refinement of the acoustic source is necessary for in vivo studies and clinical translation. The source parameters for use in vivo were defined, and a transducer was fabricated for transcutaneous exposure of porcine and human iliofemoral deep-vein thrombosis (DVT) as the target. Based on the design criteria, a 1.5-MHz elliptical source with a 6-cm focal length and a focal gain of 60 was selected. The source was characterized by fiber-optic hydrophone and holography. High-speed photography showed that the cavitation cloud could be confined to dimensions smaller than the specified vessel lumen. The source was also demonstrated in vitro to create confined lesions within clots. The results support that this design offers an appropriate clinical prototype for combined histotripsy-thrombolytic therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.