ArticleScience advances2021
An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A screen for stress-induced sleep genes in Caenorhabditis elegans reveals a role for glutamate signaling.Genetics · 2026Article
- Mechanosensory encoding of surface mechanics optimizes locomotion.Nature communications · 2026Article
- Nonlinear stiffness of NompC gating spring and its implication in mechanotransduction.Science advances · 2026Article
- Bright calcium-modulated bioluminescent indicators for activity imaging and red photon-assisted synaptic transmission.bioRxiv : the preprint server for biology · 2026Article
- Obstacles Regulate Membrane Tension Propagation to Enable Localized Mechanotransduction.bioRxiv : the preprint server for biology · 2025Article
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- The neuron-intrinsic membrane skeleton is required for motor neuron integrity throughout lifespan.bioRxiv : the preprint server for biology · 2025Article
- Tailorable biosensors for real-time monitoring of stress distribution in soft biomaterials and living tissues.Nature communications · 2025Article
- Hierarchical behavior control by a single class of interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans.Developmental cell · 2024Article
- Additive Manufacturing Provides Infinite Possibilities for Self-Sensing Technology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Automated dual olfactory device for studying head/tail chemosensation inAPL bioengineering · 2024Article
- Opticool: Cutting-edge transgenic optical tools.PLoS genetics · 2024Review
- Can repetitive mechanical motion cause structural damage to axons?Frontiers in molecular neuroscience · 2024Review
- A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing.Nature cell biology · 2023Article
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- FLInt: single shot safe harbor transgene integration via Fluorescent Landmark Interference.G3 (Bethesda, Md.) · 2023Article
- Mechanosensitive membrane proteins: Usual and unusual suspects in mediating mechanotransduction.The Journal of general physiology · 2023Article
- Axonal plasticity in response to active forces generated through magnetic nano-pulling.Cell reports · 2023Article
- Scalable Electrophysiology of Millimeter-Scale Animals with Electrode Devices.BME frontiers · 2023Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A repetitive gait cycle is an archetypical component within the behavioral repertoire of many animals including humans. It originates from mechanical feedback within proprioceptors to adjust the motor program during locomotion and thus leads to a periodic orbit in a low-dimensional space. Here, we investigate the mechanics, molecules, and neurons responsible for proprioception in Caenorhabditis elegans to gain insight into how mechanosensation shapes the orbital trajectory to a well-defined limit cycle. We used genome editing, force spectroscopy, and multiscale modeling and found that alternating tension and compression with the spectrin network of a single proprioceptor encodes body posture and informs TRP-4/NOMPC and TWK-16/TREK2 homologs of mechanosensitive ion channels during locomotion. In contrast to a widely accepted model of proprioceptive “stretch” reception, we found that proprioceptors activated locally under compressive stresses in-vivo and in-vitro and propose that this property leads to compartmentalized activity within long axons delimited by curvature-dependent mechanical stresses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.