ArticleJournal of periodontology2022
Combined association of cognitive impairment and poor oral health on mortality risk in older adults: Results from the NHANES with 15 years of follow-up.
Article in Journal of periodontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Deteriorated oral health and function as risk factors for physical disability and mortality in community-dwelling older adults: a systematic review and meta-analysis.European geriatric medicine · 2026Pooled it
- Dental healthcare utilization and mortality: a population-based prospective cohort study in southern Sweden.Acta odontologica Scandinavica · 2026Article
- Healthy Dietary Pattern Improves Cognitive Function in Elderly Persons With Periodontitis: A Cross-Sectional Study of NHANES.International dental journal · 2025Article
- Examining the Impact of Natural Teeth Trajectory on Mortality Among CLHLS.International dental journal · 2025Article
- Combined association of gait speed and processing speed on cardiometabolic disease mortality risk in the US older adults: a prospective cohort study from NHANES.Frontiers in aging neuroscience · 2025Article
- Article
- Cross-Sectional Analysis of Periodontal Disease and Cognitive Impairment Conducted in a Memory Clinic: The Pearl Study.Journal of Alzheimer's disease : JAD · 2023Article
- Coffee consumption and all-cause and cardiovascular mortality in older adults: should we consider cognitive function?Frontiers in nutrition · 2023Article
- Oral Health and Mortality Among Older Adults: A Doubly Robust Survival Analysis.American journal of preventive medicine · 2023Article
- Serum Antioxidant Vitamins Mediate the Association between Periodontitis and Metabolically Unhealthy Overweight/Obesity.Nutrients · 2022Article
- Periodontitis and cognitive impairment in older adults: The mediating role of mitochondrial dysfunction.Journal of periodontology · 2022Article
- Combined association of cognitive impairment and poor oral health on mortality risk in older adults: Results from the NHANES with 15 years of follow-up.Journal of periodontology · 2022Article
- The Association between Number of Teeth and Cognitive Frailty in Older Adults: A Cross-Sectional Study.The journal of nutrition, health & aging · 2022Article
- Serum α-Klotho associated with oral health among a nationally representative sample of US adults.Frontiers in endocrinology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment and poor oral health are frequently seen among older adults. Both conditions have been identified as risk factors for mortality. However, the combined associations of cognitive impairment and poor oral health with mortality have not been well studied and are therefore the aim of this cohort study.
methodsWe analyzed data from the National Health and Nutrition Examination Survey (1999-2002) linked with mortality data obtained from the 2015 public-use linked mortality file. Cognitive impairment was defined as a digit symbol substitution test score lower than the lowest quartile. Oral health status was assessed based on presence of untreated caries, moderate to severe periodontitis, and edentulism. The combined effects of caries/periodontitis or edentulism and cognitive impairment on all-cause and cardiometabolic mortality were examined using the Cox proportional hazard models after adjusting for potential confounders including demographic characteristics, lifestyle, biomarkers, and comorbidities.
resultsIn total, 1973 participants were enrolled in the prospective study. At a median follow-up of 13.4 years, 978 participants had died (264 deaths because of cardiometabolic disease). Cognitive impairment, periodontitis, and edentulism were each found to be significant predictors of all-cause mortality. Caries, however, was not significantly related to mortality. When analyzing these predictors in combination, a diagnosis of cognitive impairment and periodontitis was associated with an 83.1% increase in all-cause mortality risk and an 87.7% increase in cardiometabolic mortality risk compared with healthy controls. Similarly, the risk for all-cause mortality was highest in cases where impaired cognition and edentulism co-occurred (adjusted hazard ratio = 1.701, 1.338-2.161).
conclusionConcomitant presence of cognitive impairment and periodontitis or edentulism can be associated with a higher risk of mortality among older U.S. adults.
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