Evidence map›Paper›PMID 34533755›Full record

ArticleJournal of natural medicines2022

Phenylpropanoid-conjugated iridoid glucosides from leaves of Morinda morindoides.

Yasinjan Hashim, Kazufumi Toume, Shusaku Mizukami, Toshinori Kitami, Mayumi Taniguchi, Awet Alem Teklemichael, Yuki Tayama, Nguyen Tien Huy, José Nzunzu Lami, Joseph M Bodi and 2 more

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Yasinjan HashimSection of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Kazufumi ToumeSection of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. toume@inm.u-toyama.ac.jp.ORCID http://orcid.org/0000-0002-3315-145X
Shusaku MizukamiDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0002-7722-4884
Toshinori KitamiSection of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Mayumi TaniguchiDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
Awet Alem TeklemichaelDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
Yuki TayamaDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.
Nguyen Tien HuyDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0002-9543-9440
José Nzunzu LamiFaculty of Pharmaceutical Sciences, Laboratory of Pharmaceutics and Phytopharmaceutical Drug Development, University of Kinshasa, B.P. 212, Kinshasa XI, Democratic Republic of the Congo.
Joseph M BodiFaculty of Medicine, Department of Pediatrics, Emergency and Intensive Care Unit, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo.
Kenji HirayamaDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0001-9467-1777
Katsuko KomatsuSection of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan. katsukok@inm.u-toyama.ac.jp.ORCID http://orcid.org/0000-0002-0833-7199
Nagasaki University · JPUniversity of Toyama · JPUniversity of Kinshasa · CD

Funding

the joint usage/research center on tropical disease, institute of tropical medicine, nagasaki university 2016-Ippan-20the joint usage/research center on tropical disease, institute of tropical medicine, nagasaki university 2017-Ippan-16the joint usage/research center on tropical disease, institute of tropical medicine, nagasaki university 2018-Ippan-20the joint usage/research center on tropical disease, institute of tropical medicine, nagasaki university 2019-Ippan-22
6 · The paper itself

Abstract

Three phenylpropanoid-conjugated iridoid glucosides, acetylgaertneric acid (1), acetyldehydrogaertneroside (2), and dehydrogaertneric acid (10), together with nine known related iridoid glucosides (3-9, 11, and 12), two coumaroyl alkaloids, one benzenoid, and three flavonoid glucosides were isolated from leaves of Morinda morindoides (Rubiaceae). Structures of these isolated compounds were determined using spectroscopic analysis. Compounds 1-18 and previously isolated compounds (19-29) were evaluated for anti-trypanosomal activity against Trypanosoma cruzi Tulahuen strain (trypomastigote and amastigote) together with cytotoxicity against host cells, new-born mouse heart cells. Among them, molucidin (21) and prismatomerin (22) exhibited good anti-trypanosomal activity (IC

Indexed as

MorindaRubiaceaeAnimalsIridoid GlucosidesIridoidsMicePlant ExtractsPlant LeavesIridoid GlucosidesIridoidsPlant ExtractsIridoidMorinda morindoidesPhenylpropanoid-conjugated iridoid glucosidesTrypanosomaTrypanosoma cruzi

Identifiers

PMID34533755
OpenAlexW3200193678

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.