Evidence map›Paper›PMID 34533647›Full record

ArticleMolecular and cellular biochemistry2022

The anti-tumour effect of induced pluripotent stem cells against submandibular gland carcinoma in rats is achieved via modulation of the apoptotic response and the expression of Sirt-1, TGF-β, and MALAT-1 in cancer cells.

Eman Mohamed Faruk, Dina Sabry, Ahmed A Morsi, Yasmine Alaa El-Din, Neama M Taha, Engy Medhat

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Eman Mohamed FarukDepartment of Histology and Cytology, Faculty of Medicine, Benha University, Benha, Egypt.
Dina SabryDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ahmed A MorsiDepartment of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Fayoum Governorate, Egypt. ahmed_saqr4@yahoo.com.ORCID http://orcid.org/0000-0001-7911-0795
Yasmine Alaa El-DinDepartment of Oral Pathology, Faculty of Dentistry, October 6 University, Giza, Egypt.
Neama M TahaDepartment of Physiology, Umm Al-Qura University, Mecca, Kingdom of Saudi Arabia.
Engy MedhatDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Cairo University · EGUmm al-Qura University · SAFayoum University · EGOctober 6 University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The era of induced pluripotent stem cells (iPSCs) was used as novel biotechnology to replace embryonic stem cells bypassing the ethical concerns and problems of stem cell transplant rejection. The anti-tumour potential of iPSCs against many tumours including salivary cancer was proven in previous studies. The current study aimed to investigate the contribution of the Bax, Sirt-1, TGF-β, and MALAT genes and/or their protein expression to the pathogenesis of submandibular carcinogenesis before and after iPSCs treatment. Thirty Wistar albino rats were equally assigned into three groups: group I (control), group II (Squamous cell carcinoma (SCC)): submandibular glands were injected SCC cells, and group III (SCC/iPSCs): SCC rats were treated by 5 × 10

Indexed as

ApoptosisCarcinoma, Squamous CellInduced Pluripotent Stem CellsSalivary Gland NeoplasmsAnimalsbcl-2-Associated X ProteinCell Line, TumorMaleRatsRats, WistarRNA, Long NoncodingRNA, NeoplasmSirtuin 1Submandibular GlandTransforming Growth Factor betaBax protein, ratbcl-2-Associated X ProteinMALAT1 long noncoding RNA, ratRNA, Long NoncodingRNA, NeoplasmSirt1 protein, ratSirtuin 1Transforming Growth Factor betaImmunohistochemistryInduced pluripotent stem cellslncRNAMALAT-1Sirt-1Submandibular salivary cancerTGF-β gene expressions

Identifiers

PMID34533647
OpenAlexW3200523452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.