Evidence map›Paper›PMID 34533543›Full record

ArticleAllergologie select2021

COVID-19 vaccination and allergen immunotherapy (AIT) - A position paper of the German Society for Applied Allergology (AeDA) and the German Society for Allergology and Clinical Immunology (DGAKI).

Ludger Klimek, Oliver Pfaar, Eckard Hamelmann, Jörg Kleine-Tebbe, Christian Taube, Martin Wagenmann, Thomas Werfel, Randolf Brehler, Natalija Novak, Norbert Mülleneisen and 2 more

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Article in Allergologie select, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Ludger KlimekCenter for Rhinology and Allergology, Wiesbaden.
Oliver PfaarDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg.
Eckard HamelmannUniversity Hospital for Pediatrics and Adolescent Medicine, Children's Center Bethel, University of Bielefeld.
Jörg Kleine-TebbeAllergy Center Westend, Berlin.
Christian TaubeDepartment of Pneumology, University Hospital Essen - Ruhrlandklinik, Essen.
Martin WagenmannDepartment of Otorhinolaryngology, University Hospital Düsseldorf, Düsseldorf.
Thomas WerfelDepartment of Dermatology, Allergology and Venerology, Hanover Medical School.
Randolf BrehlerCenter for Rhinology and Allergology, Wiesbaden.
Natalija NovakDepartment of Dermatology and Allergy, Polyclinic for Dermatology and Allergology, Bonn.
Norbert MülleneisenAsthma and Allergy Center, Leverkusen.
Sven BeckerClinic for Otorhinolaryngology, University Hospital, Tübingen, and.
Margitta WormAllergology and Immunology, Clinic for Dermatotology, Venerology and Allergology, Charité Universitätsmedizin Berlin, Germany.
Zentrum für Rhinologie und Allergologie · DECharité - Universitätsmedizin Berlin · DEPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVaccinations against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are intended to induce an immune response to protect against infection/disease. Allergen immunotherapy (AIT) is thought to induce a (different) immune response, e.g., to induce tolerance to allergens. In this position paper we clarify how to use AIT in temporal relation to COVID-19 vaccination. Four SARS-CoV-2 vaccines are currently approved in the EU, and their possible immunological interactions with AIT are described together with practical recommendations for use. MATERIALS AND

methodsBased on the internationally published literature, this position paper provides specific recommendations for the use of AIT in temporal relation to a SARS-CoV-2 vaccination.

resultsAIT is used in 1) allergic rhinitis, 2) allergic bronchial asthma, 3) insect venom allergy, 4) food allergy (peanut).

conclusionFor the continuation of an ongoing AIT, we recommend an interval of 1 week before and after vaccination for subcutaneous immunotherapy (SCIT). For sublingual immunotherapy (SLIT) and oral immunotherapy (OIT), we recommend taking them up to the day before vaccination and a break of 2 - 7 days after vaccination. Initiation of a new SCIT, SLIT, or OIT should be delayed until 1 week after the day of the second vaccination. For SCIT, we generally recommend an interval of ~ 1 week to COVID-19 vaccination.

Indexed as

allergen immunotherapyallergic rhinitisasthmaCOVID-19SARS-CoV-2

Identifiers

PMID34533543
PMCPMC8439106
OpenAlexW3198887374

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.