ArticleEndocrine connections2021
Low serum levels of bone turnover markers are associated with perirenal fat thickness in patients with type 2 diabetes mellitus.
Article in Endocrine connections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes.World journal of diabetes · 2025Article
- Molecular insights into the interplay between type 2 diabetes mellitus and osteoporosis: implications for endocrine health.Frontiers in endocrinology · 2024Review
- Perirenalfat thickness is associated with bone turnover markers and bone mineral density in postmenopausal women with type 2 diabetes mellitus.Frontiers in endocrinology · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is known as a common risk factor for osteoporosis and type 2 diabetes mellitus (T2DM). Perirenal fat, surrounding the kidneys, has been reported to be unique in anatomy and biological functions. This study aimed to explore the relationship between perirenal fat and bone metabolism in patients with T2DM.
methodsA total of 234 patients with T2DM were recruited from September 2019 to December 2019 in the cross-sectional study. The biochemical parameters and bone turnover markers (BTMs) were determined in all participants. Perirenal fat thickness (PrFT) was performed by ultrasounds via a duplex Doppler apparatus. Associations between PrFT and bone metabolism index were determined via correlation analysis and regression models.
resultsThe PrFT was significantly correlated with β-C-terminal telopeptides of type I collagen (β-CTX) (r = -0.14, P < 0.036), parathyroid hormone (iPTH) (r = -0.18, P ≤ 0.006), and 25 hydroxyvitamin D (25-OH-D) (r = -0.14, P = 0.001). Multivariate analysis confirmed that the association of PrFT and β-CTX (β = -0.136, P = 0.042) was independent of other variables.
conclusionThis study showed a negative and independent association between PrFT and β-CTX in subjects with T2DM, suggesting a possible role of PrFT in bone metabolism. Follow-up studies and further research are necessary to validate the associations and to elucidate the underlying mechanisms.
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