ArticleThe journal of physical chemistry letters2021
Hydration Forces Dominate Surface Charge Dependent Lipid Bilayer Interactions under Physiological Conditions.
Article in The journal of physical chemistry letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Beyond Membrane Fluidity: Lipid Unsaturation and Hofmeister Cations Govern Nanoplastic Dynamics at Membrane Interfaces.Analytical chemistry · 2026Article
- Tunable Lipid Coatings Enable Cytoplasmic siRNA Delivery by DNA Origami.ACS applied materials & interfaces · 2026Article
- The role of hydration in the removal of glyphosate (GLY) and aminomethylphosphonic acid (AMPA) by nanofiltration membranes.Nature communications · 2026Article
- Electrically Switchable Molecular Adhesion via Self-Assembled Monolayer-Mediated Hydration and Ion Structuring.Journal of the American Chemical Society · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid bilayer interactions are essential to a vast range of biological functions, such as intracellular transport mechanisms. Surface charging mediated by concentration dependent ion adsorption and desorption on lipid headgroups alters electric double layers as well as van der Waals and steric hydration forces of interacting bilayers. Here, we directly measure bilayer interactions during charge modulation in a symmetrically polarized electrochemical three-mirror interferometer surface forces apparatus. We quantify polarization and concentration dependent hydration and electric double layer forces due to cation adsorption/desorption. Our results demonstrate that exponential hydration layer interactions effectively describe surface potential dependent surface forces due to cation adsorption at high salt concentrations. Hence, electric double layers of lipid bilayers are exclusively dominated by inner Helmholtz charge regulation under physiological conditions. These results are important for rationalizing bilayer behavior under physiological conditions, where charge and concentration modulation may act as biological triggers for function and signaling.
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