Evidence map›Paper›PMID 34533265›Full record

ReviewDermatologic therapy2021

Pityriasis rosea-like cutaneous eruption as a possible dermatological manifestation after Oxford-AstraZeneca vaccine: Case report and brief literature review.

Maria Cristina Pedrazini, Mariliza Henrique da Silva

Open access · bronzeAbstract readCase ReportsReview
In one paragraph

Review in Dermatologic therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Article
  7. L-Lysine as an Alternative Treatment for Pityriasis Rosea (PR) [Response to Letter].Clinical, cosmetic and investigational dermatology · 2024
    Article
  8. L-lysine as an Alternative Treatment for Pityriasis Rosea (PR) [Letter].Clinical, cosmetic and investigational dermatology · 2024
    Article
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  11. Review
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  19. Inverse pityriasis rosea secondary to COVID-19 vaccination.Proceedings (Baylor University. Medical Center) · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria Cristina PedraziniProfessor - Department of Dental Sciences, Faculdade de Odontologia e Centro de Pesquisas São Leopoldo Mandic, Campinas, São Paulo State, Brazil.ORCID 0000-0002-7649-6626
Mariliza Henrique da SilvaInfectious Disease Specialist - Department of Infectiology Diagnosis, State Program STI/AIDS Reference and Training Center of São Paulo, São Paulo, São Paulo State, Brazil.ORCID 0000-0003-2194-8805
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pityriasis rosea (PR) has been manifested in patients suffering from COVID-19 as well as after vaccine protocols against SARS-CoV-2. It has a possible association with the HHV-6B virus (roseola infantum) and can be controlled by antivirals such as acyclovir as well as by the amino acid l-Lysine that showed a positive result in reducing the number of lesions and healing time. The aim of this study was to report a case of PR after a second dose of Oxford-AstraZeneca, the adopted therapy and a brief literature review. A 53-year-old woman, phototype II, presented an erythematous lesion in the posterior right thigh 15 days after the second dose of Oxford-AstraZeneca vaccine. Eight days after the initial injury, new injuries appeared in the calf, buttocks and thighs. The diagnosis was PR with a 5-week eruption cycle. The treatment consisted of the use of l-Lysine, 3 grams loading dose and 500 mg for 30 days and moisturizing/healing lotion, starting 14 days after the herald patch. After the 5th week of the disease cycle, there were no new eruptions and the repair cycle continued for up to 8 weeks leaving some residual skin spots. It is concluded that the patient may be a carrier a latent virus, HHV-6, and the vaccine administration with immune system stimulation, would have activated the possible virus causing PR. l-Lysine helped to control the manifestation by limiting the number of lesions and their location, which were restricted to the legs, thighs and buttocks.

Indexed as

COVID-19Herpesvirus 7, HumanPityriasis RoseaVaccinesFemaleHumansMiddle AgedSARS-CoV-2Vaccinesamino acidAstraZenecahuman herpesvirus 6-7l-Lysinepityriasis roseavaccine

Identifiers

PMID34533265
PMCPMC8646511
OpenAlexW3200276301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.