ArticleHuman brain mapping2021
Aberrant functional brain network dynamics in patients with functional constipation.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence and influencing factors of functional constipation in Chinese children and adolescents: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Tai Chi's synergistic modulation on autonomic nervous activity and central autonomic networks in functional constipation patients: a randomized controlled trial.Scientific reports · 2025Trial
- Exploring brain activity differences in functional constipation using fNIRS: a case-control study.Journal of neuroengineering and rehabilitation · 2026Article
- Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Task-Dependent Cortical Oscillatory Dynamics in Functional Constipation.Sensors (Basel, Switzerland) · 2025Article
- Abnormal connection between the posterior insula and the gastric network among patients with functional constipation.Frontiers in human neuroscience · 2025Article
- Effectiveness and possible brain mechanisms of cervical invasive vagus nerve stimulation (iVNS) intervention for avoidant/restrictive food intake disorder: a case report.Psychoradiology · 2024Article
- Imaging and clinical predictors of acute constipation in patients with acute ischemic stroke.Frontiers in neuroscience · 2023Article
- Alterations in functional connectivity and interactions in resting-state networks in female patients with functional constipation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Aberrant resting-state functional connectivity and topological properties of the subcortical network in functional dyspepsia patients.Frontiers in molecular neuroscience · 2022Article
- The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia.Frontiers in neuroscience · 2022Article
- Aberrant functional brain network dynamics in patients with functional constipation.Human brain mapping · 2021Article
- Abnormal Static and Dynamic Functional Connectivity in Left and Right Temporal Lobe Epilepsy.Frontiers in neuroscience · 2021Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aberrant static functional connectivity of brain network has been widely investigated in patients with functional constipation (FCon). However, the dynamics of brain functional connectivity in FCon patients remained unknown. This study aimed to detect the brain dynamics of functional connectivity states and network topological organizations of FCon patients and investigate the correlations of the aberrant brain dynamics with symptom severity. Eighty-three FCon patients and 80 healthy subjects (HS) were included in data analysis. The spatial group independent component analysis, sliding-window approach, k-means clustering, and graph-theoretic analysis were applied to investigate the dynamic temporal properties and coupling patterns of functional connectivity states, as well as the time-variation of network topological organizations in FCon patients. Four reoccurring functional connectivity states were identified in k-means clustering analysis. Compared to HS, FCon patients manifested the lower occurrence rate and mean dwell time in the state with a complex connection between default mode network and cognitive control network, as well as the aberrant anterior insula-cortical coupling patterns in this state, which were significantly correlated with the symptom severity. The graph-theoretic analysis demonstrated that FCon patients had higher sample entropy at the nodal efficiency of anterior insula than HS. The current findings provided dynamic perspectives for understanding the brain connectome of FCon and laid the foundation for the potential treatment of FCon based on brain connectomics.
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