Evidence map›Paper›PMID 34533174›Full record

ArticleNanoscale2021

Enhanced target-specific delivery of docetaxel-loaded nanoparticles using engineered T cell receptors.

William J McDaid, Nikolai Lissin, Ellen Pollheimer, Michelle Greene, Adam Leach, Peter Smyth, Giovanna Bossi, Daniel Longley, David K Cole, Christopher J Scott

Open access · hybridAbstract read
In one paragraph

Article in Nanoscale, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

William J McDaidThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK, BT9 7AE. c.scott@qub.ac.uk.
Nikolai LissinImmunocore Ltd, 101 Park Dr, Milton, Abingdon, United Kingdom OX14 4RY.
Ellen PollheimerThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK, BT9 7AE. c.scott@qub.ac.uk.
Michelle GreeneThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK, BT9 7AE. c.scott@qub.ac.uk.
Adam LeachThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK, BT9 7AE. c.scott@qub.ac.uk.
Peter SmythThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK, BT9 7AE. c.scott@qub.ac.uk.
Giovanna BossiImmunocore Ltd, 101 Park Dr, Milton, Abingdon, United Kingdom OX14 4RY.
Daniel LongleyThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK, BT9 7AE. c.scott@qub.ac.uk.
David K ColeImmunocore Ltd, 101 Park Dr, Milton, Abingdon, United Kingdom OX14 4RY.ORCID http://orcid.org/0000-0003-0028-9396
Christopher J ScottThe Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK, BT9 7AE. c.scott@qub.ac.uk.ORCID http://orcid.org/0000-0002-7582-3808
Queen's University Belfast · GBImmunocore (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For effective targeted therapy of cancer with chemotherapy-loaded nanoparticles (NPs), antigens that are selective for cancer cells should be targeted to minimise off-tumour toxicity. Human leukocyte antigens (HLAs) are attractive cancer targets as they can present peptides from tumour-selective proteins on the cell surface, which can be recognised by T cells

Indexed as

NanoparticlesReceptors, Antigen, T-CellAntigens, NeoplasmCell Line, TumorDocetaxelHumansT-LymphocytesAntigens, NeoplasmDocetaxelReceptors, Antigen, T-Cell

Identifiers

PMID34533174
PMCPMC8447836
OpenAlexW3195811346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.