Evidence map›Paper›PMID 34533054›Full record

ReviewJournal of the American Heart Association2021

Evolving Diagnostic Criteria for Arrhythmogenic Cardiomyopathy.

Domenico Corrado, Alessandro Zorzi, Alberto Cipriani, Barbara Bauce, Riccardo Bariani, Giorgia Beffagna, Manuel De Lazzari, Federico Migliore, Kalliopi Pilichou, Alessandra Rampazzo and 5 more

Abstract readReview
In one paragraph

Review in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Disease models and AAV therapies ofMolecular therapy. Advances · 2026
    Review
  10. State-of-the-Art in Echocardiographic Strain Imaging of Arrhythmogenic Cardiomyopathy.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Integral Role of Cardiac Imaging in the Electrophysiology Field.The Journal of innovations in cardiac rhythm management · 2025
    Review
  17. Review
  18. AAV9-mediated gene supplementation therapy prevents and rescues arrhythmogenic cardiomyopathy in Pnpla2-mutated mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  19. Article
  20. Review

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Domenico CorradoDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0003-1487-0392
Alessandro ZorziDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0002-3578-0583
Alberto CiprianiDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0001-7842-6202
Barbara BauceDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0001-7357-293X
Riccardo BarianiDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0002-9120-8709
Giorgia BeffagnaDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.
Manuel De LazzariDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.
Federico MiglioreDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0001-8574-9421
Kalliopi PilichouDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0003-3646-0669
Alessandra RampazzoDepartment of Biology University of Padova Italy.ORCID 0000-0003-3884-8843
Ilaria RigatoDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.
Stefania RizzoDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0002-8575-1748
Gaetano ThieneDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0002-8814-2577
Martina Perazzolo MarraDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.
Cristina BassoDepartment of Cardiac, Thoracic and Vascular Sciences and Public Health University of Padova Italy.ORCID 0000-0002-0195-9753

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Criteria for diagnosis of arrhythmogenic cardiomyopathy (ACM) were first proposed in 1994 and revised in 2010 by a Task Force. Although the Task Force criteria demonstrated a good accuracy for diagnosis of the original right ventricular phenotype (arrhythmogenic right ventricular cardiomyopathy), they lacked sensitivity for identification of the expanding phenotypic spectrum of ACM, which includes left-sided variants and did not incorporate late-gadolinium enhancement findings by cardiac magnetic resonance. The 2020 International criteria ("Padua criteria") have been developed by International experts with the aim to improve the diagnosis of ACM by providing new criteria for the diagnosis of left ventricular phenotypic features. The key upgrade was the incorporation of tissue characterization findings by cardiac magnetic resonance for noninvasive detection of late-gadolinium enhancement/myocardial fibrosis that are determinants for characterization of arrhythmogenic biventricular and left ventricular cardiomyopathy. The 2020 International criteria are heavily dependent on cardiac magnetic resonance, which has become mandatory to characterize the ACM phenotype and to exclude other diagnoses. New criteria regarding left ventricular depolarization and repolarization ECG abnormalities and ventricular arrhythmias of left ventricular origin were also provided. This article reviews the evolving approach to diagnosis of ACM, going back to the 1994 and 2010 International Task Force criteria and then grapple with the modern 2020 International criteria.

Indexed as

CardiomyopathiesArrhythmogenic Right Ventricular DysplasiaContrast MediaGadoliniumHumansContrast MediaGadoliniumcardiac magnetic resonancecardiomyopathydiagnosissudden deathventricular arrhythmia

Identifiers

PMID34533054
PMCPMC8649536

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.