ArticleJournal of neuropsychology2022
Assessment of apathy in neurological patients using the Apathy Motivation Index caregiver version.
Article in Journal of neuropsychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Repetitive transcranial magnetic stimulation for apathy in patients with neurodegenerative conditions, cognitive impairment, stroke, and traumatic brain injury: a systematic review.Frontiers in psychiatry · 2023Pooled it
- Apathy as a Risky Neuropsychiatric Syndrome of Progression From Normal Aging to Mild Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- Working Memory Deficits in Hippocampal Amnesia are Associated with Apathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- On the relationships between apathy, depression and anhedonia.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- The social dimension of apathy: evidence for a distinct domain from 11,243 individuals across health and neurocognitive disorders.Translational psychiatry · 2026Article
- Discrepant Views of Apathy in Patients and Caregivers: the Role of Cognitive Deficits in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Unveiling discrepancies in depression detection among persons with dementia: A comparative analysis of caregiver and self-report.Journal of Alzheimer's disease : JAD · 2026Article
- The Development of a Program to Identify and Manage Apathy in Residents with Korsakoff's Syndrome: A Qualitative Exploration of Patient, Family Caregiver, and Professional Caregiver Perspectives.Geriatrics (Basel, Switzerland) · 2025Article
- The associations between caregivers' psychological characteristics and patients' apathy symptoms in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.Brain : a journal of neurology · 2025Article
- A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy.Movement disorders clinical practice · 2025Article
- Self- versus caregiver-reported apathy across neurological disorders.Brain communications · 2025Article
- Association between apathy and caregiver burden in patients with amyotrophic lateral sclerosis: a cross-sectional study.BMJ open · 2024Article
- Probing apathy in children and adolescents with the Apathy Motivation Index-Child version.Behavior research methods · 2024Article
- An Update on Apathy in Alzheimer's Disease.Geriatrics (Basel, Switzerland) · 2023Review
- Role of serotonin in modulation of decision-making in Parkinson's disease.Journal of psychopharmacology (Oxford, England) · 2023Article
- Coordination and Cognition in Pure Nutritional Wernicke's Encephalopathy with Cerebellar Degeneration after COVID-19 Infection: A Unique Case Report.Journal of clinical medicine · 2023Article
- Distinguishing apathy from depression: A review differentiating the behavioral, neuroanatomic, and treatment-related aspects of apathy from depression in neurocognitive disorders.International journal of geriatric psychiatry · 2023Review
- Apathy and effort-based decision-making in Alzheimer's disease and subjective cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Apathy is a common, disabling neuropsychiatric syndrome that occurs across many brain disorders and may be associated with diminished motivation in behavioural, cognitive, emotional and social domains. Assessment is complicated by the variability of symptoms across apathy domains and self-report from patients, which can be misleading due to their lack of insight. Independent evaluation by clinicians also has limitations though if it has to be performed with limited time. Caregiver reports are a viable alternative, but current assessments for them either do not distinguish between different apathy domains or are interview-based and take long to administer. In this study, we developed a brief caregiver questionnaire version of the recently developed Apathy Motivation Index (AMI), which is a self-report tool. We confirmed three apathy factors in this new caregiver measure (AMI-CG) that were also present in the AMI: Behavioural Activation, Emotional Sensitivity and Social Motivation. Furthermore, we validated the scores against more extensive caregiver interviews using the established Lillle apathy rating scale as well as patient self-reports of apathy, measures of depression, anhedonia, cognition, activities of daily living and caregiver burden across four different neurological conditions: Parkinson's disease, Alzheimer's disease, subjective cognitive impairment and limbic encephalitis. The AMI-CG showed good internal reliability, external validity and diagnostic accuracy. It also uncovered cases of social apathy overlooked by traditional instruments. Crucially, patients who under-rated their apathy compared to informants were more likely to have difficulties performing everyday activities and to be a greater burden to caregivers. The findings provide evidence for a multidimensional conceptualization of apathy and an instrument for efficient detection of apathy based on caregiver reports for use in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.