Evidence map›Paper›PMID 34532720›Full record

ArticleAgeing and neurodegenerative diseases2021

Diverse midbrain dopaminergic neuron subtypes and implications for complex clinical symptoms of Parkinson's disease.

Kathleen Carmichael, Breanna Sullivan, Elena Lopez, Lixin Sun, Huaibin Cai

Abstract read
In one paragraph

Article in Ageing and neurodegenerative diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  13. TARGET-seq: Linking single-cell transcriptomics of human dopaminergic neurons with their target specificity.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Article
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  18. Article
  19. Beyond dopamine: exploring endocannabinoids in Parkinson's disease.Ageing and neurodegenerative diseases · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kathleen CarmichaelTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Breanna SullivanTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Elena LopezTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Lixin SunTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Huaibin CaiTransgenic Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

Molecular and Pathophysiological Study of Parkinson's DiseaseZIAAG000928 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2011 to 2025
$15.8M
The Function and Pathogenic Mechanisms of LRRK2/Dardarin in Parkinson's DiseaseZIAAG000944 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2009 to 2025
$10.2M
The Function and Pathogenic Mechanisms of LRRK2/Dardarin in Parkinson's DiseaseZ01AG000944 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2008 to 2008
$499k
Intramural NIH HHS Z01 AG000944Intramural NIH HHS ZIA AG000928Intramural NIH HHS ZIA AG000944
6 · The paper itself

Abstract

Parkinson's disease (PD), the most common degenerative movement disorder, is clinically manifested with various motor and non-motor symptoms. Degeneration of midbrain

Indexed as

ageingALDH1A1dopaminedopaminergic neuronsParkinson’s diseaseRNA sequencingSNcsubpopulationVTA

Identifiers

PMID34532720
PMCPMC8442626

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.