Evidence map›Paper›PMID 34532702›Full record

ArticlemicroPublication biology2021

Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response.

Brandon J Berry, Tyrone O Nieves, Andrew P Wojtovich

Open access · greenAbstract read
In one paragraph

Article in microPublication biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. BlingLifeJournal of microbiology and biotechnology · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Brandon J BerryUniversity of Rochester Medical Center, Department of Anesthesiology and Perioperative Medicine, 575 Elmwood Ave., Rochester NY, 14642 Box 711/604.
Tyrone O NievesUniversity of Rochester Medical Center, Department of Anesthesiology and Perioperative Medicine, 575 Elmwood Ave., Rochester NY, 14642 Box 711/604.
Andrew P WojtovichUniversity of Rochester Medical Center, Department of Anesthesiology and Perioperative Medicine, 575 Elmwood Ave., Rochester NY, 14642 Box 711/604.
University of Rochester Medical Center · US

Funding

Mitochondrial ROS Microdomains and Neuronal IschemiaR01NS092558 · NINDS · UNIVERSITY OF ROCHESTER · PI WOJTOVICH, ANDREW PHILLIP · 2015 to 2025
$3.7M
Mitochondrial Energy Sensing and Neuronal IschemiaR01NS115906 · NINDS · UNIVERSITY OF ROCHESTER · PI Andrew P Wojtovich · 2020 to 2026
$3.0M
NINDS NIH HHS R01 NS092558NINDS NIH HHS R01 NS115906
6 · The paper itself

Abstract

Mitochondria are ATP-producing organelles that also signal throughout the cell. Mitochondrial protein homeostasis is regulated through membrane potential-dependent protein import and quality control signaling. The mitochondrial unfolded protein response (UPR

Identifiers

PMID34532702
PMCPMC8438586
OpenAlexW3199819248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.