Evidence map›Paper›PMID 34532463›Full record

ArticleAnnals of translational medicine2021

Genomic instability-associated lncRNA signature predicts prognosis and distinct immune landscape in gastric cancer.

Jie Sun, Quan Jiang, Hao Chen, Qi Zhang, Junjie Zhao, Haojie Li, Xuefei Wang, Yong Fang, Yuanyuan Ruan, Yihong Sun

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Observational
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  8. LncRNA and its role in gastric cancer immunotherapy.Frontiers in cell and developmental biology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jie SunDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Quan JiangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Hao ChenDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Qi ZhangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Junjie ZhaoDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Haojie LiDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Xuefei WangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yong FangDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Yuanyuan RuanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yihong SunDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Fudan University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCharacterized by multiple features, genomic stability-related markers, such as microsatellite instability (MSI), were regulated as an important predictor of chemotherapy and immunity responses in cancer treatment. The aim of our study was to identify a genomic instability-associated long non-coding RNA (lncRNA) signature to help predict the survival and therapy response of gastric cancers (GCs).

methodsWe used RNA sequencing and single nucleotide variant (SNV) data from The Cancer Genome Atlas-stomach adenocarcinoma (TCGA-STAD) datasets to explore genomic instability-associated lncRNAs. Hierarchical cluster analyses of 197 differentially expressed genomic instability-associated lncRNAs were performed to separate GC patients into two groups, namely, the genomically unstable (GU)-like group and the genomically stable (GS)-like group.

resultsCox regression analysis was conducted to finally identify six lncRNAs (LINC02678, HOXA10-AS, RHOXF1-AS1, AC010789.1, LINC01150, and TGFB2-AS1) with independent prognostic value to establish the genomic instability-associated lncRNA signature (GILncSig). Based on the SNV analysis, GILncSig was correlated with accumulation of gene mutation counts. Further comparisons between different risk score groups were performed to assess chemotherapy drug sensitivity and immune landscape variations.

conclusionsOur study not only revealed the genomic instability-associated lncRNAs in GCs, but provided a key method and resource for further studies of the role of these lncRNAs play, and introduced a potential new way to identify genomic instability-associated cancer biomarkers.

Indexed as

Gastric cancer (GC)genomic instabilityimmune landscapelong non-coding RNAs (lncRNAs)The Cancer Genome Atlas (TCGA)

Identifiers

PMID34532463
PMCPMC8422092
OpenAlexW3190454043

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.