Evidence map›Paper›PMID 34532452›Full record

ArticleAnnals of translational medicine2021

Application of contrast-enhanced ultrasound in the diagnosis of burn depth.

Xue Jiang, Feng Li, Yunfei Chi, Xin Chen, Yukun Luo, Qinggui Ye, Wenjing Song, Guoping Li

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xue JiangDepartment of Ultrasound Diagnosis, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Feng LiBurns and Plastic Department, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Yunfei ChiBurns and Plastic Department, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Xin ChenBurns and Plastic Department, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Yukun LuoDepartment of Ultrasound Diagnosis, The First Medical Center of PLA General Hospital, Beijing, China.
Qinggui YeDepartment of Ultrasound Diagnosis, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Wenjing SongDepartment of Ultrasound Diagnosis, The Fourth Medical Center of PLA General Hospital, Beijing, China.
Guoping LiGrand Life Science & Technology, Ltd., Beijing, China.
Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe diagnosis of burn depth often relies on the subjective judgment of plastic surgeons. Contrast-enhanced ultrasound (CEUS) can visualize the microcirculation well and has potential value in diagnosing the depth of burn wounds. We assessed the depth of the burn wounds by CEUS, and compared the results with histological examination.

methodsTwo rhesus monkeys were used, and multiple burn wounds with different depths were made on their backs. The echo of the dermis and subcutaneous tissue were observed for each wound, and the thickness of the dermis was measured. CEUS was performed to evaluate the depth of burn wounds and compared with pathological results.

results(I) After scalding, dermal tissue edema occurred, and the thickness of the dermis measured by a US tended to increase gradually, related to the time of scalding and the order of measurement. (II) With the prolongation of the burn time, the depth of filling by contrast agent gradually increased, from the superficial dermis to the deep dermis and subcutaneous tissue, indicating that the depth of tissue damage gradually increased. This was consistent with the pathological observation. The thickness of the healthy dermis was about 1.3-1.8 mm, and 2.7-4.1 mm after scalding. The depth of the burn wounds was 0.9-4.1 mm, accounting for 32-100% of the full skin thickness.

conclusionsCEUS is a convenient and fast examination method that is consistent with pathological diagnosis of the depth of burn wounds and could prove valuable for the accurate assessment of burn injuries.

Indexed as

animal studycontrast-enhanced ultrasound (CEUS)Cutaneous burnspathological diagnosis

Identifiers

PMID34532452
PMCPMC8422095
OpenAlexW3193758148

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.