Evidence map›Paper›PMID 34532410›Full record

ArticleAnnals of translational medicine2021

Analysis of the retinal capillary plexus layers in a murine model with diabetic retinopathy: effect of intravitreal injection of human CD34

Kong Wa Cheung, Amirfarbod Yazdanyar, Christian Dolf, Whitney Cary, Nicholas Marsh-Armstrong, Jan A Nolta, Susanna S Park

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Animal models for the evaluation of retinal stem cell therapies.Progress in retinal and eye research · 2025
    Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Advantages of ocular regeneration research.Annals of translational medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kong Wa CheungDepartment of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, CA, USA.
Amirfarbod YazdanyarDepartment of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, CA, USA.
Christian DolfDepartment of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, CA, USA.
Whitney CaryDepartment of Internal Medicine, Stem Cell Program and Gene Therapy Center, University of California Davis, Sacramento, CA, USA.
Nicholas Marsh-ArmstrongDepartment of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, CA, USA.
Jan A NoltaDepartment of Internal Medicine, Stem Cell Program and Gene Therapy Center, University of California Davis, Sacramento, CA, USA.
Susanna S ParkDepartment of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, CA, USA.
University of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic retinopathy is a retinal vasculopathy involving all three retinal capillary plexus layers. Since human CD34

methodsStreptozotocin (STZ)-induced diabetic mice were injected intravitreally with 50,000 human CD34

resultsThree distinct retinal capillary plexus layers were visualized and imaged using confocal microscopy. Eyes that received intravitreal injection of CD34

conclusionsThe protective effect of intravitreal injection of the human CD34

Indexed as

Confocal microscopydiabetic retinopathyhuman CD34+ stem cellsretinal flat-mountretinal vascular plexus

Identifiers

PMID34532410
PMCPMC8421965
OpenAlexW3095821627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.