ArticleVirus evolution2021
The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein.
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Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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29citing papers in PubMed, 1 pooled it
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- SARS-CoV-2 Genomic Surveillance in Brazil: A Systematic Review with Scientometric Analysis.Viruses · 2022Pooled it
- Compressive pangenomics using mutation-annotated networks.Nature genetics · 2026Article
- Structural and functional dissection of neutralisation differences among SARS-CoV-2 variants using antigenicity prediction and CR3022 binding analysis.Frontiers in immunology · 2026Article
- Mapping the viral battlefield: SARS-CoV-2 infection dynamics among healthcare workers in Brazil.Human resources for health · 2025Article
- Dispersion patterns of SARS-CoV-2 variants Gamma, Lambda and Mu in Latin America and the Caribbean.Nature communications · 2024Article
- A Narrative Overview of Coronavirus Infection: Clinical Signs and Symptoms, Viral Entry and Replication, Treatment Modalities, and Management.Current topics in medicinal chemistry · 2024Review
- Insertion and deletion mutations preserved in SARS-CoV-2 variants.Archives of microbiology · 2023Article
- Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves.Journal of clinical medicine · 2023Article
- Convergent Evolution in SARS-CoV-2 Spike Creates a Variant Soup from Which New COVID-19 Waves Emerge.International journal of molecular sciences · 2023Review
- Molnupiravir: From Hope to Epic Fail?Viruses · 2022Article
- A Preliminary Genomic Analysis of the Omicron Variants of SARS-CoV-2 in Central India During the third wave of the COVID-19 Pandemic.Archives of medical research · 2022Article
- Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status.Virus evolution · 2022Article
- SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape.Life science alliance · 2022Article
- SARS-CoV-2 Delta variant isolates from vaccinated individuals.BMC genomics · 2022Article
- Clinical and genomic data of sars-cov-2 detected in maternal-fetal interface during the first wave of infection in Brazil.Microbes and infection · 2022Article
- Emergence of a recurrent insertion in the N-terminal domain of the SARS-CoV-2 spike glycoprotein.Virus research · 2022Article
- Spread of Gamma (P.1) Sub-Lineages Carrying Spike Mutations Close to the Furin Cleavage Site and Deletions in the N-Terminal Domain Drives Ongoing Transmission of SARS-CoV-2 in Amazonas, Brazil.Microbiology spectrum · 2022Article
- Article
- Transmission cluster of COVID-19 cases from Uruguay: emergence and spreading of a novel SARS-CoV-2 ORF6 deletion.Memorias do Instituto Oswaldo Cruz · 2022Article
- Emergence of SARS-CoV-2 New Variants and Their Clinical Significance.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Review
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Authors and funding
37 authors at 7 institutions in 1 country.
Paola Cristina ResendeLaboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.ORCID https://orcid.org/0000-0002-2884-3662
Felipe G NavecaLaboratório de Ecologia de Doenças Transmissíveis na Amazônia (EDTA), Instituto Leônidas e Maria Deane, FIOCRUZ-Amazonas, Rua Teresina, 476. Adrianópolis, Manaus 69.057-070, Brazil.
Roberto D LinsDepartment of Virology, Instituto Aggeu Magalhães, FIOCRUZ-Pernambuco, Av. Professor Moraes Rego, s/n - Cidade Universitária, Recife 50.740-465, Brazil.
Filipe Zimmer DezordiDepartamento de Entomologia, Instituto Aggeu Magalhães, FIOCRUZ-Pernambuco, Av. Professor Moraes Rego, s/n - Cidade Universitária, Recife 50.740-465, Brazil.
Matheus V F FerrazDepartment of Virology, Instituto Aggeu Magalhães, FIOCRUZ-Pernambuco, Av. Professor Moraes Rego, s/n - Cidade Universitária, Recife 50.740-465, Brazil.
Emerson G MoreiraDepartment of Virology, Instituto Aggeu Magalhães, FIOCRUZ-Pernambuco, Av. Professor Moraes Rego, s/n - Cidade Universitária, Recife 50.740-465, Brazil.
Danilo F CoêlhoDepartment of Virology, Instituto Aggeu Magalhães, FIOCRUZ-Pernambuco, Av. Professor Moraes Rego, s/n - Cidade Universitária, Recife 50.740-465, Brazil.ORCID https://orcid.org/0000-0002-1111-0825
Fernando Couto MottaLaboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.
Anna Carolina Dias PaixãoLaboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.
Luciana AppolinarioLaboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.
Renata Serrano LopesLaboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.
Ana Carolina da Fonseca MendonçaLaboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.
Alice Sampaio Barreto da RochaLaboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.
Valdinete NascimentoLaboratório de Ecologia de Doenças Transmissíveis na Amazônia (EDTA), Instituto Leônidas e Maria Deane, FIOCRUZ-Amazonas, Rua Teresina, 476. Adrianópolis, Manaus 69.057-070, Brazil.
Victor SouzaLaboratório de Ecologia de Doenças Transmissíveis na Amazônia (EDTA), Instituto Leônidas e Maria Deane, FIOCRUZ-Amazonas, Rua Teresina, 476. Adrianópolis, Manaus 69.057-070, Brazil.
George SilvaLaboratório de Ecologia de Doenças Transmissíveis na Amazônia (EDTA), Instituto Leônidas e Maria Deane, FIOCRUZ-Amazonas, Rua Teresina, 476. Adrianópolis, Manaus 69.057-070, Brazil.
Fernanda NascimentoLaboratório de Ecologia de Doenças Transmissíveis na Amazônia (EDTA), Instituto Leônidas e Maria Deane, FIOCRUZ-Amazonas, Rua Teresina, 476. Adrianópolis, Manaus 69.057-070, Brazil.
Lidio Gonçalves Lima NetoLaboratório Central de Saúde Pública do Estado do Maranhão (LACEN-MA), Rua João Luís, Bairro Diamente, Sao Luis 65020-320, Brazil.
Fabiano Vieira da SilvaLaboratório Central de Saúde Pública do Estado do Maranhão (LACEN-MA), Rua João Luís, Bairro Diamente, Sao Luis 65020-320, Brazil.
Irina RiedigerLaboratório Central de Saúde Pública do Estado do Paraná (LACEN-PR), Rua Ubaldino do Amaral 545 - Alto da XV, Curitiba 80060-190, Brazil.
Maria do Carmo DeburLaboratório Central de Saúde Pública do Estado do Paraná (LACEN-PR), Rua Ubaldino do Amaral 545 - Alto da XV, Curitiba 80060-190, Brazil.
Anderson Brandao LeiteLaboratório Central de Saúde Pública do Estado do Alagoas (LACEN-AL), Av. Marechal Castelo Branco, 1773 Jatiúca, Alagoas, 57030340 Brazil.
Tirza MattosLaboratório Central de Saúde Pública do Amazonas (LACEN-AM), Rua Emílio Moreira, 528 - Centro, Manaus 69020-040, Brazil.
Cristiano Fernandes da CostaFundação de Vigilância em Saúde do Amazonas, Av. Torquato Tapajós, 4.010 Colônia Santo Antônio, Manaus 69.093-018, Brazil.
Felicidade Mota PereiraLaboratório Central de Saúde Pública do Estado da Bahia (LACEN-BA), Rua Waldemar Falcão, 123 - Bairro Brotas, Salvador 40295-001, Brazil.
Cliomar Alves Dos SantosLaboratório Central de Saúde Pública do Estado de Sergipe (LACEN-SE), Rua Campo do Brito, 551 - Bairro São José, Aracajú, Sergipe 49020-380, Brazil.
Darcita Buerger RovarisLaboratório Central de Saúde Pública do Estado de Santa Catarina (LACEN-SC), Avenida Rio Branco, 152 - Fundos, Florianópolis, Santa Catarina 88015-201, Brazil.
Sandra Bianchini FernandesLaboratório Central de Saúde Pública do Estado de Santa Catarina (LACEN-SC), Avenida Rio Branco, 152 - Fundos, Florianópolis, Santa Catarina 88015-201, Brazil.
Adriano AbbudInstituto Adolfo Lutz, Av. Dr. Arnaldo, 351, São Paulo 01246-000, Brazil.ORCID https://orcid.org/0000-0003-1685-0619
Claudio SacchiInstituto Adolfo Lutz, Av. Dr. Arnaldo, 351, São Paulo 01246-000, Brazil.
Ricardo KhouriLaboratório de Enfermidades Infecciosas Transmitidas por Vetores, Instituto Gonçalo Moniz, FIOCRUZ-Bahia, Rua Waldemar Falcão, 121, Candeal, Salvador, Bahia 40296-710 , Brazil.ORCID https://orcid.org/0000-0001-5664-4436
André Felipe Leal BernardesLaboratório Central de Saúde Pública do Estado de Minas Gerais (LACEN-MG), Rua Conde Pereira Carneiro, 80 - Gameleira, Belo Horizonte 30510-010, Brazil.
Edson DelatorreDepartamento de Biologia, Centro de Ciências Exatas, Naturais e da Saúde, Universidade Federal do Espírito Santo, Av. Fernando Ferrari, 514 - Goiabeira, Alegre 29075-910, Brazil.
Tiago GräfPlataforma de Vigilância Molecular, Instituto Gonçalo Moniz, FIOCRUZ-Bahia, Rua Waldemar Falcão, 121, Candeal, Salvador 40296-710, Brazil.ORCID https://orcid.org/0000-0003-4921-7975
Marilda Mendonça SiqueiraLaboratory of Respiratory Viruses and Measles (LVRS), Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.
Gonzalo BelloLaboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, FIOCRUZ-Rio de Janeiro, Av. Brasil, 4365 - Manguinhos, Rio de Janeiro 21040-900, Brazil.
Gabriel L WallauDepartamento de Entomologia, Instituto Aggeu Magalhães, FIOCRUZ-Pernambuco, Av. Professor Moraes Rego, s/n - Cidade Universitária, Recife 50.740-465, Brazil.ORCID https://orcid.org/0000-0002-1419-5713
Fundação Oswaldo Cruz · BRUniversidade Federal de Pernambuco · BRInstituto Adolfo Lutz · BRSecretaria da Saúde · BRFundação de Medicina Tropical · BRUniversidade Estadual de Ciências da Saúde de Alagoas · BRUniversidade Federal do Espírito Santo · BR
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. Importantly, we detected the community transmission of different P.1 lineages bearing NTD indels ∆69-70 (which can impact several SARS-CoV-2 diagnostic protocols), ∆144 and ins214ANRN, and a new VOI N.10 derived from the B.1.1.33 lineage carrying three NTD deletions (∆141-144, ∆211, and ∆256-258). These findings support that the ongoing widespread transmission of SARS-CoV-2 in Brazil generates new viral lineages that might be more resistant to antibody neutralization than parental variants of concern.
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antibody escapecommunity transmissionCOVID-19pandemicsSARS-CoV-2
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