Evidence map›Paper›PMID 34532060›Full record

ArticleVirus evolution2021

RV144 vaccine imprinting constrained HIV-1 evolution following breakthrough infection.

Eric Lewitus, Eric Sanders-Buell, Meera Bose, Anne Marie O'Sullivan, Kultida Poltavee, Yifan Li, Hongjun Bai, Thembi Mdluli, Gina Donofrio, Bonnie Slike and 30 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 7 institutions in 2 countries.

Eric LewitusUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Eric Sanders-BuellUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Meera BoseUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Anne Marie O'SullivanUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Kultida PoltaveeUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Yifan LiUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.ORCID https://orcid.org/0000-0001-7038-2671
Hongjun BaiUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.ORCID https://orcid.org/0000-0002-3501-3974
Thembi MdluliUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Gina DonofrioUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Bonnie SlikeUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Hong ZhaoDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA.
Kim WongDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA.
Lennie ChenDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA.
Shana MillerUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Jenica LeeUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Bahar AhaniUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Steven LeporeUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Sevan MuhammadUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Rebecca GrandeUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Ursula TranUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Vincent DussuptUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Letzibeth Mendez-RiveraUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Sorachai NitayaphanUS Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Jaranit KaewkungwalUS Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Punnee PitisuttithumMahidol University, Nakhon Pathom, Thailand.
Supachai Rerks-NgarmThai Ministry of Public Health, Nonthaburi, Thailand.
Robert J O'ConnellUS Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Holly JanesFred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.ORCID https://orcid.org/0000-0002-3237-984X
Peter B GilbertFred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.
Robert GramzinskiUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Sandhya VasanUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Merlin L RobbUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Nelson L MichaelCenter for Infectious Disease Research, WRAIR, Silver Spring, MD 20910, USA.
Shelly J KrebsUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Joshua T HerbeckDepartment of Global Health, University of Washington, Seattle, WA 98195, USA.
Paul T EdlefsenFred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.
James I MullinsDepartment of Microbiology, University of Washington, Seattle, WA 98195, USA.
Jerome H KimUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Sodsai TovanabutraUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Morgane RollandUS Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.ORCID https://orcid.org/0000-0003-3650-8490
Henry M. Jackson Foundation · USUniversity of Washington · USArmed Forces Research Institute of Medical Science · THFred Hutch Cancer Center · USWalter Reed Army Institute of Research · USMahidol University · THMinistry of Public Health · TH

Funding

SDMC: HIV Vaccine Trials NetworkUM1AI068635 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Peter B. Gilbert, Yunda Huang · 2011 to 2026
$385.9M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
NIAID NIH HHS P30 AI027757NIAID NIH HHS UM1 AI068635
6 · The paper itself

Abstract

The scale of the HIV-1 epidemic underscores the need for a vaccine. The multitude of circulating HIV-1 strains together with HIV-1's high evolvability hints that HIV-1 could adapt to a future vaccine. Here, we wanted to investigate the effect of vaccination on the evolution of the virus post-breakthrough infection. We analyzed 2,635 HIV-1

Indexed as

HIV-1sieve analysisvaccinewithin-host evolution

Identifiers

PMID34532060
PMCPMC8438874
OpenAlexW3169353175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.