Evidence map›Paper›PMID 34532059›Full record

ArticleVirus evolution2021

Phylogenetic analysis of HIV-1 shows frequent cross-country transmission and local population expansions.

Marc Bennedbæk, Anna Zhukova, Man-Hung Eric Tang, Jaclyn Bennet, Paula Munderi, Kiat Ruxrungtham, Magnus Gisslen, Michael Worobey, Jens D Lundgren, Rasmus L Marvig

Abstract read
In one paragraph

Article in Virus evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. HIV Transmission Dynamics in Greater Mexico City are Shaped by Dense Spatial Mixing.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. HIV infection.Nature reviews. Disease primers · 2023
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marc BennedbækCentre of Excellence for Health, Immunity and Infection (CHIP), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-2753-5991
Anna ZhukovaUnité Bioinformatique Evolutive, Hub Bioinformatique et Biostatistique, USR3756 (C3BI//DBC), Institut Pasteur and CNRS, 25-28 Rue du Dr Roux, 75015 Paris, France.
Man-Hung Eric TangCentre of Excellence for Health, Immunity and Infection (CHIP), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Jaclyn BennetClinical HIV Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of Witwatersrand, 1 Jan Smuts Avenue, Braamfontein 2000, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-8826-0453
Paula MunderiMRC Uganda Research Unit on AIDS, UVRI P.O.Box 49, Plot 51-59 Nakiwogo Road, Entebbe-Uganda.
Kiat RuxrungthamHIV-NAT, Thai Red Cross AIDS Research Center, and School of Global Health, Faculty Medicine, Chulalongkorn University, Chamchuri 5 Bld. 6th Fl., Phayathai Rd., Wangmai, Pathumwan Bangkok 10330, Thailand.
Magnus GisslenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Universitetsplatsen 1, 405 30 Gothenburg, Sweden.
Michael WorobeyDepartment of Ecology and Evolutionary Biology, University of Arizona, Biological Sciences West, Rm. 324 Tucson, AZ 85721, USA.
Jens D LundgrenCentre of Excellence for Health, Immunity and Infection (CHIP), Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-8901-7850
Rasmus L MarvigDepartment of Genomic Medicine, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-5267-3173

Funding

International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)UM1AI068641 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2011 to 2014
$83.5M
International Network for Strategic Initiatives in Global HIV Trials (INSIGHT): STARTUM1AI120197 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2015 to 2017
$65.1M
Extended follow-up of randomized participants in the INSIGHT START trialU01AI136780 · NIAID · UNIVERSITY OF MINNESOTA · PI GRUND, BIRGIT, REILLY, CAVAN S. · 2019 to 2024
$18.0M
Molecular Archeology of HIVR01AI084691 · NIAID · UNIVERSITY OF ARIZONA · PI WOROBEY, MICHAEL · 2011 to 2014
$1.2M
NIAID NIH HHS R01 AI084691NIAID NIH HHS U01 AI136780NIAID NIH HHS UM1 AI068641NIAID NIH HHS UM1 AI120197
6 · The paper itself

Abstract

Understanding of pandemics depends on the characterization of pathogen collections from well-defined and demographically diverse cohorts. Since its emergence in Congo almost a century ago, Human Immunodeficiency Virus Type 1 (HIV-1) has geographically spread and genetically diversified into distinct viral subtypes. Phylogenetic analysis can be used to reconstruct the ancestry of the virus to better understand the origin and distribution of subtypes. We sequenced two 3.6-kb amplicons of HIV-1 genomes from 3,197 participants in a clinical trial with consistent and uniform sampling at sites across 35 countries and analyzed our data with another 2,632 genomes that comprehensively reflect the HIV-1 genetic diversity. We used maximum likelihood phylogenetic analysis coupled with geographical information to infer the state of ancestors. The majority of our sequenced genomes (

Indexed as

Ancestral State ReconstructionHIVPhylogeneticsPhylogeographyTransmission

Identifiers

PMID34532059
PMCPMC8438898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.