ArticleFood science & nutrition2021
Dandelion sterol improves diabetes mellitus-induced renal injury in in vitro and in vivo study.
Article in Food science & nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Beneficial effects of food-medicine homologous herbs for patients with diabetic kidney disease.Frontiers in immunology · 2025Review
- Natural compounds improve diabetic nephropathy by regulating the TLR4 signaling pathway.Journal of pharmaceutical analysis · 2024Review
- CircACTR2 attenuated the effects of tetramethylpyrazine on human kidney cell injury.Journal of bioenergetics and biomembranes · 2024Article
- Effects of dandelion root on rat heart function and oxidative status.BMC complementary medicine and therapies · 2023Article
- A Novel Approach Based on Gut Microbiota Analysis and Network Pharmacology to Explain the Mechanisms of Action ofDrug design, development and therapy · 2023Article
- Dandelion sterol improves diabetes mellitus-induced renal injury in in vitro and in vivo study.Food science & nutrition · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of our research was to evaluate Dandelion sterol's treatment effects on diabetes mellitus-induced renal injury in in vitro and in vivo study. The rats were divided into five groups as normal control (Ctrl), diabetic nephropathy model (Model), Dandelion sterol low-dose treated (Dan-Low), Dandelion sterol middle-dose treated (Dan-Middle), and Dandelion sterol high-dose treated (Dan-High). Measuring serum TNF-α, IL-1β, and IL-6 concentrations by Elisa assay, evaluate kidney pathology by HE staining, kidney cell apoptosis of TUNEL, TLR4, and NF-κB(p65) proteins expression by IHC assay, and relative gene expressions by RT-qPCR assay. In the following step, using HK-2 treated with high glucose to model DN cell model to discuss the relative mechanisms, evaluate TNF-α, IL-1β, and IL-6 concentrations by Elisa assay, evaluate cell apoptosis by flow cytometry, evaluate TLR4 and NF-κB(p65) proteins expression by WB assay, relative gene expression by RT-qPCR assay, and NF-κB(p65) nuclear volume by cellular immunofluorescence. Compared with Ctrl group, TNF-α, IL-1β, and IL-6 concentrations and apoptosis cell number were significantly increased, TLR4/NF-κB(p65) pathway was significantly stimulated in Model rats and cell groups. With Dan supplement, the diabetic-induced renal injury was significantly improved (
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