Evidence map›Paper›PMID 34531976›Full record

ArticlePulmonary circulation

Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization.

Mingmei Xiong, Pritesh P Jain, Jiyuan Chen, Aleksandra Babicheva, Tengteng Zhao, Mona Alotaibi, Nick H Kim, Ning Lai, Amin Izadi, Marisela Rodriguez and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  8. Article
  9. TRPC6, a therapeutic target for pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 2 countries.

Mingmei XiongSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Pritesh P JainSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Jiyuan ChenSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Aleksandra BabichevaSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Tengteng ZhaoSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Mona AlotaibiDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, CA, USA.
Nick H KimDivision of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, CA, USA.
Ning LaiSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Amin IzadiSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Marisela RodriguezSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Jifeng LiSection of Physiology, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-0418-6151
Angela BalistrieriSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Francesca BalistrieriSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Sophia ParmisanoSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Xin SunDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Daniela Voldez-JassoDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
John Y-J ShyyDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Patricia A ThistlethwaiteDepartment of Surgery, University of California, San Diego, La Jolla, CA, USA.
Jian WangSection of Physiology, University of California, San Diego, La Jolla, CA, USA.
Ayako MakinoDivision of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0003-1259-8604
Jason X-J YuanSection of Physiology, University of California, San Diego, La Jolla, CA, USA.ORCID https://orcid.org/0000-0002-0685-4862
University of California San Diego · USUniversity of California System · USCapital Medical University · CN

Funding

Ion Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL135807 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUAN, JASON X J · 2017 to 2023
$5.6M
Molecular Mechanisms of Pulmonary HypertensionR01HL070852 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THISTLETHWAITE, PATRICIA A · 2002 to 2011
$3.1M
Role of Gap Junction in Hypoxia-induced Pulmonary HypertensionR01HL146764 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAKINO, AYAKO · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL070852NHLBI NIH HHS R01 HL146764NHLBI NIH HHS R35 HL135807
6 · The paper itself

Abstract

Pulmonary arterial hypertension is a progressive and fatal disease and rodents with experimental pulmonary hypertension (PH) are often used to study pathogenic mechanisms, identify therapeutic targets, and develop novel drugs for treatment. Here we describe a hands-on set of experimental approaches including ex vivo lung angiography and histology and in vivo right heart catheterization (RHC) to phenotypically characterize pulmonary hemodynamics and lung vascular structure in normal mice and mice with experimental PH. We utilized Microfil polymer as contrast in our ex vivo lung angiogram to quantitatively examine pulmonary vascular remodeling in mice with experimental PH, and lung histology to estimate pulmonary artery wall thickness. The peripheral lung vascular images were selected to determine the total length of lung vascular branches, the number of branches and the number of junctions in a given area (mm

Indexed as

animal modelexperimental pulmonary hypertension in micelung angiogrampulmonary hemodynamicsright heart catheterization

Identifiers

PMID34531976
PMCPMC8438952
OpenAlexW3192883323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.